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Involvement of the IL23Th17 Pathway in the Pathogenesis of Tunisian Pemphigus Foliaceus
Joint Authors
Fakhfakh, Raouia
Ben Jmaa, M.
Abida, O.
Bahloul, E.
Sellami, Kh.
Gaddour, L.
Elloumi, N.
Ben Ayed, M.
Masmoudi, A.
Dhouib, M.
Abdelmoula, M.
Mahfoudh, N.
Makni, H.
Turki, H.
Masmoudi, H.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Pemphigus foliaceus (PF) is a rare autoimmune skin disease caused by anti-Dsg1 pathogenic autoantibodies.
It is considered as a Th2-mediated disease.
Likewise, Th17 cells were recently described in the pathogenesis of the disease but their role is still unclear.
We aimed to unravel the eventual implication of the IL23/Th17 pathway in the development of PF.
A case-control study was conducted on 115 PF patients and 201 healthy controls using PCR-RFLP and AS-PCR methods.
SNPs in IL23R, RORγt, IL17A, IL17F, IL17AR, TNFa, and STAT3 genes were genotyped.
mRNA expression of IL23R and RORγt was evaluated using Q-PCR.
The frequency of circulating Th17 cells was analyzed by flow cytometry.
Genetic associations between IL23R>rs11209026, IL17A>rs3748067, IL17F>rs763780, and TNFa>rs1800629 and the susceptibility to PF were reported.
Moreover, we revealed a significant increased frequency of circulating CD4+IL17+ cells as well as higher mRNA levels of RORγt and IL23R in PBMCs of patients.
However, no significant increase of RORγt and IL23R mRNA expression was observed in lesional skin biopsies.
In spite of the little size of specimens, our results provide converging arguments for the contribution of the IL23/Th17 pathway in the pathogenesis of PF.
American Psychological Association (APA)
Ben Jmaa, M.& Abida, O.& Fakhfakh, Raouia& Bahloul, E.& Sellami, Kh.& Gaddour, L.…[et al.]. 2018. Involvement of the IL23Th17 Pathway in the Pathogenesis of Tunisian Pemphigus Foliaceus. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1204290
Modern Language Association (MLA)
Ben Jmaa, M.…[et al.]. Involvement of the IL23Th17 Pathway in the Pathogenesis of Tunisian Pemphigus Foliaceus. Mediators of Inflammation No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1204290
American Medical Association (AMA)
Ben Jmaa, M.& Abida, O.& Fakhfakh, Raouia& Bahloul, E.& Sellami, Kh.& Gaddour, L.…[et al.]. Involvement of the IL23Th17 Pathway in the Pathogenesis of Tunisian Pemphigus Foliaceus. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1204290
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204290