The Radioprotective Effect of Procaine and Procaine-Derived Product Gerovital H3 in Lymphocytes from Young and Aged Individuals
Joint Authors
Moreno-Villanueva, María
Ungurianu, Anca
Margina, Denisa
Borsa, Claudia
Ionescu, Cristina
von Scheven, Gudrun
Oziol, Lucie
Faure, Philippe
Artur, Yves
Gradinaru, Daniela
Bürkle, Alexander
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ionizing radiation induces genomic instability in living organisms, and several studies reported an ageing-dependent radiosensitivity.
Chemical compounds, such as scavengers, radioprotectors, and modifiers, contribute to reducing the radiation-associated toxicity.
These compounds are often antioxidants, and therefore, in order to be effective, they must be present before or during exposure to radiation.
However, not all antioxidants provide radioprotection.
In this study, we investigated the effects of procaine and of a procaine-based product Gerovital H3 (GH3) on the formation of endogenous and X-ray-induced DNA strand breaks in peripheral blood mononuclear cells (PBMCs) isolated from young and elderly individuals.
Interestingly, GH3 showed the strongest radioprotective effects in PBMCs from young subjects, while procaine reduced the endogenous amount of DNA strand breaks more pronounced in aged individuals.
Both procaine and GH3 inhibited lipid peroxidation, but procaine was more effective in inhibiting mitochondria free radicals’ generation, while GH3 showed a higher antioxidant action on macrophage-induced low-density lipoprotein oxidation.
Our findings provide new insights into the mechanisms underlying the distinct effects of procaine and GH3 on DNA damage.
American Psychological Association (APA)
Ungurianu, Anca& Margina, Denisa& Borsa, Claudia& Ionescu, Cristina& von Scheven, Gudrun& Oziol, Lucie…[et al.]. 2020. The Radioprotective Effect of Procaine and Procaine-Derived Product Gerovital H3 in Lymphocytes from Young and Aged Individuals. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1204300
Modern Language Association (MLA)
Ungurianu, Anca…[et al.]. The Radioprotective Effect of Procaine and Procaine-Derived Product Gerovital H3 in Lymphocytes from Young and Aged Individuals. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1204300
American Medical Association (AMA)
Ungurianu, Anca& Margina, Denisa& Borsa, Claudia& Ionescu, Cristina& von Scheven, Gudrun& Oziol, Lucie…[et al.]. The Radioprotective Effect of Procaine and Procaine-Derived Product Gerovital H3 in Lymphocytes from Young and Aged Individuals. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1204300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204300