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CRP Stimulates GDF15 Expression in Endothelial Cells through p53
Joint Authors
Noren Hooten, Nicole
Evans, Michele K.
Kim, Yoonseo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Growth differentiation factor 15 (GDF15) is a multifunctional, secreted protein that is a direct target gene of p53.
GDF15 is a prospective biomarker of cardiovascular disease (CVD).
C-reactive protein (CRP), like GDF15, is implicated in inflammation and an independent biomarker of CVD.
However, the molecular interactions between GDF15 and CRP remain unexplored.
In women, we found a significant relationship between hsCRP and GDF15 serum and mRNA levels.
In vitro treatment of cultured human aortic endothelial cells (HAECs) with purified CRP or transfection of a CRP plasmid into HAECs induced GDF15 expression.
Dual-luciferase reporter assays confirmed that CRP significantly increased the levels of GDF15 promoter luciferase activity, indicating that CRP induces GDF15 transcription.
Chromatin immunoprecipitation (ChIP) assays confirmed that p53 was recruited to both p53 binding sites 1 and 2 in the GDF15 promoter in response to CRP.
We have uncovered a linkage between CRP and GDF15, a new clue that could be important in the pathogenesis of endothelial inflammation.
American Psychological Association (APA)
Kim, Yoonseo& Noren Hooten, Nicole& Evans, Michele K.. 2018. CRP Stimulates GDF15 Expression in Endothelial Cells through p53. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1204302
Modern Language Association (MLA)
Kim, Yoonseo…[et al.]. CRP Stimulates GDF15 Expression in Endothelial Cells through p53. Mediators of Inflammation No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1204302
American Medical Association (AMA)
Kim, Yoonseo& Noren Hooten, Nicole& Evans, Michele K.. CRP Stimulates GDF15 Expression in Endothelial Cells through p53. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1204302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204302