The Role of Regulatory T Cell in Nontypeable Haemophilus influenzae-Induced Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Joint Authors

Gibson, Peter G.
Wang, Fang
Pang, Zhiqiang
Wang, Guoqiang
Ran, Nan
Wang, Ziyan
Lu, Junying
Guo, Yingqiao
Guan, Xuewa
Lu, Yanjiao
Chen, Fang
Fang, Keyong
Yuan, Yuze

Source

Mediators of Inflammation

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-03-13

Country of Publication

Egypt

No. of Pages

14

Main Subjects

Diseases

Abstract EN

Chronic obstructive pulmonary disease (COPD) is associated with irreversible persistent airflow limitation and enhanced inflammation.

The episodes of acute exacerbation (AECOPD) largely depend on the colonized pathogens such as nontypeable Haemophilus influenzae (NTHi), one of the most commonly isolated bacteria.

Regulatory T cells (Tregs) are critical in controlling inflammatory immune responses and maintaining tolerance; however, their role in AECOPD is poorly understood.

In this study, we hypothesized a regulatory role of Tregs, as NTHi participated in the progress of COPD.

Immunological pathogenesis was investigated in a murine COPD model induced by cigarette smoke (CS).

NTHi was administrated through intratracheal instillation for an acute exacerbation.

Weight loss and lung function decline were observed in smoke-exposed mice.

Mice in experimental groups exhibited serious inflammatory responses via histological and cytokine assessment.

Expression levels of Tregs and Th17 cells with specific cytokines TGF-β1 and IL-17 were detected to assess the balance of pro-/anti-inflammatory influence partially.

Our findings suggested an anti-inflammatory activity of Tregs in CS-induced model.

But this activity was suppressed after NTHi administration.

Collectively, these data suggested that NTHi might play a necessary role in downregulating Foxp3 to impair the function of Tregs, helping development into AECOPD.

American Psychological Association (APA)

Guan, Xuewa& Lu, Yanjiao& Wang, Guoqiang& Gibson, Peter G.& Chen, Fang& Fang, Keyong…[et al.]. 2018. The Role of Regulatory T Cell in Nontypeable Haemophilus influenzae-Induced Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1204316

Modern Language Association (MLA)

Guan, Xuewa…[et al.]. The Role of Regulatory T Cell in Nontypeable Haemophilus influenzae-Induced Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Mediators of Inflammation No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1204316

American Medical Association (AMA)

Guan, Xuewa& Lu, Yanjiao& Wang, Guoqiang& Gibson, Peter G.& Chen, Fang& Fang, Keyong…[et al.]. The Role of Regulatory T Cell in Nontypeable Haemophilus influenzae-Induced Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1204316

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1204316