Curcumin, a Multifaceted Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and Apoptosis
Joint Authors
Petit, Patrice
Rainey, Nathan Earl
Moustapha, Aoula
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-20
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Curcumin has extensive therapeutic potential because of its antioxidant, anti-inflammatory, and antiproliferative properties.
Multiple preclinical studies in vitro and in vivo have proven curcumin to be effective against various cancers.
These potent effects are driven by curcumin’s ability to induce G2/M cell cycle arrest, induce autophagy, activate apoptosis, disrupt molecular signaling, inhibit invasion and metastasis, and increase the efficacy of current chemotherapeutics.
Here, we focus on the hormetic behavior of curcumin.
Frequently, low doses of natural chemical products activate an adaptive stress response, whereas high doses activate acute responses like autophagy and cell death.
This phenomenon is often referred to as hormesis.
Curcumin causes cell death and primarily initiates an autophagic step (mitophagy).
At higher doses, cells undergo mitochondrial destabilization due to calcium release from the endoplasmic reticulum, and die.
Herein, we address the complex crosstalk that involves mitochondrial biogenesis, mitochondrial destabilization accompanied by mitophagy, and cell death.
American Psychological Association (APA)
Rainey, Nathan Earl& Moustapha, Aoula& Petit, Patrice. 2020. Curcumin, a Multifaceted Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and Apoptosis. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-23.
https://search.emarefa.net/detail/BIM-1204320
Modern Language Association (MLA)
Rainey, Nathan Earl…[et al.]. Curcumin, a Multifaceted Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and Apoptosis. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-23.
https://search.emarefa.net/detail/BIM-1204320
American Medical Association (AMA)
Rainey, Nathan Earl& Moustapha, Aoula& Petit, Patrice. Curcumin, a Multifaceted Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and Apoptosis. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-23.
https://search.emarefa.net/detail/BIM-1204320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204320