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Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva
Joint Authors
Araujo, Heitor Ceolin
Nakamune, Ana Cláudia Melo Stevanato
Garcia, Wilson Galhego
Pessan, Juliano Pelim
Antoniali, Cristina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oxidative stress biomarkers can be found at detectable concentrations in saliva.
These salivary biomarkers reflect specific oxidation pathways associated with caries and periodontitis.
Our study evaluated the influence of dental caries severity (assessed using the ICCMS™ criteria) on the levels of oxidative stress biomarkers in saliva from children.
Unstimulated saliva samples were collected from patients (from one to three years old) in a day care center in Birigui, SP, Brazil, two hours after fasting.
Children were divided into four groups (n=30/group), according to caries severity: caries free (group A), early carious lesions (group B), moderate carious lesions (group C), and advanced carious lesions (group D).
The following salivary biomarkers were determined: total proteins (TP), measured by the Lowry method; oxidative damage, measured by the TBARS method; total antioxidant capacity (TAC); superoxide dismutase (SOD) enzymatic antioxidant activity; and uric acid (UA) non-enzymatic antioxidant activity.
Data were analyzed by ANOVA, followed by the Student-Newman-Keuls test, Pearson and Spearman correlation coefficients, and multivariable linear regression (p<0.05).
TP, TAC, SOD enzymatic antioxidant activity, and UA non-enzymatic antioxidant activity increased with caries severity, consequently reducing salivary oxidative damage.
It was concluded that higher caries severity increases salivary antioxidant system activity, with consequent reduction in salivary oxidative damage.
American Psychological Association (APA)
Araujo, Heitor Ceolin& Nakamune, Ana Cláudia Melo Stevanato& Garcia, Wilson Galhego& Pessan, Juliano Pelim& Antoniali, Cristina. 2020. Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1204328
Modern Language Association (MLA)
Araujo, Heitor Ceolin…[et al.]. Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1204328
American Medical Association (AMA)
Araujo, Heitor Ceolin& Nakamune, Ana Cláudia Melo Stevanato& Garcia, Wilson Galhego& Pessan, Juliano Pelim& Antoniali, Cristina. Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1204328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204328