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Dietary n-3 PUFA May Attenuate Experimental Colitis
Joint Authors
Ghosh, Subrata
Savoye, G.
Charpentier, Cloé
Chan, Ronald
Salameh, Emmeline
Mbodji, Khaly
Ueno, Aito
Coëffier, Moïse
Guérin, Charlène
Marion-Letellier, Rachel
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Inflammatory bowel diseases (IBD) occurred in genetically predisposed people exposed to environmental triggers.
Diet has long been suspected to contribute to the development of IBD.
Supplementation with n-3 polyunsaturated fatty acids (PUFA) protects against intestinal inflammation in rodent models while clinical trials showed no benefits.
We hypothesized that intervention timing is crucial and dietary fatty acid pattern may influence intestinal environment to modify inflammation genesis.
The aim of this study was to evaluate the dietary effect of PUFA composition on intestinal inflammation.
Methods.
Animals received diet varying in their PUFA composition for four weeks before TNBS-induced colitis.
Colon inflammatory markers and gut barrier function parameters were assessed.
Inflammatory pathway PCR arrays were determined.
Results.
n-3 diet significantly decreased colon iNOS, COX-2 expression, IL-6 production, and LTB4 production but tended to decrease colon TNFα production (P=0.0617) compared to control diet.
Tight junction protein (claudin-1, occludin) expressions and MUC2 and TFF3 mRNA levels were not different among groups.
n-9 diet also decreased colon IL-6 production (P<0.05).
Conclusions.
Dietary n-3 PUFA influence colitis development by attenuating inflammatory markers.
Further research is required to better define dietary advice with a scientific rationale.
American Psychological Association (APA)
Charpentier, Cloé& Chan, Ronald& Salameh, Emmeline& Mbodji, Khaly& Ueno, Aito& Coëffier, Moïse…[et al.]. 2018. Dietary n-3 PUFA May Attenuate Experimental Colitis. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1204330
Modern Language Association (MLA)
Charpentier, Cloé…[et al.]. Dietary n-3 PUFA May Attenuate Experimental Colitis. Mediators of Inflammation No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1204330
American Medical Association (AMA)
Charpentier, Cloé& Chan, Ronald& Salameh, Emmeline& Mbodji, Khaly& Ueno, Aito& Coëffier, Moïse…[et al.]. Dietary n-3 PUFA May Attenuate Experimental Colitis. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1204330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204330