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Antioxidant Effects of Oral Ang-(1-7) Restore Insulin Pathway and RAS Components Ameliorating Cardiometabolic Disturbances in Rats
Joint Authors
Souza dos Santos, Robson Augusto
Lima, Wanderson Geraldo
Bezerra, Frank Silva
Figueiredo, Vivian Paulino
Barbosa, Maria Andrea
de Castro, Uberdan Guilherme Mendes
Zacarias, Aline Cruz
de Sá, Renata Guerra
Alzamora, Andréia Carvalho
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In prevention studies of metabolic syndrome (MetS), Ang-(1-7) has shown to improve the insulin signaling.
We evaluated the HPβCD/Ang-(1-7) treatment on lipid metabolism, renin-angiotensin system (RAS) components, oxidative stress, and insulin pathway in the liver and gastrocnemius muscle and hepatic steatosis in rats with established MetS.
After 7 weeks of high-fat (FAT) or control (CT) diets, rats were treated with cyclodextrin (HPβCD) or HPβCD/Ang-(1-7) in the last 6 weeks.
FAT-HPβCD/empty rats showed increased adiposity index and body mass, gene expression of ACE/ANG II/AT1R axis, and oxidative stress.
These results were accompanied by imbalances in the insulin pathway, worsening of liver function, hyperglycemia, and dyslipidemia.
Oral HPβCD/Ang-(1-7) treatment decreased ACE and AT1R, increased ACE2 gene expression in the liver, and restored thiobarbituric acid reactive substances (TBARS), catalase (CAT), superoxide dismutase (SOD), insulin receptor substrate (Irs-1), glucose transporter type 4 (GLUT4), and serine/threonine kinase 2 (AKT-2) gene expression in the liver and gastrocnemius muscle improving hepatic function, cholesterol levels, and hyperglycemia in MetS rats.
Overall, HPβCD/Ang-(1-7) treatment restored the RAS components, oxidative stress, and insulin signaling in the liver and gastrocnemius muscle contributing to the establishment of blood glucose and lipid homeostasis in MetS rats.
American Psychological Association (APA)
Figueiredo, Vivian Paulino& Barbosa, Maria Andrea& de Castro, Uberdan Guilherme Mendes& Zacarias, Aline Cruz& Bezerra, Frank Silva& de Sá, Renata Guerra…[et al.]. 2019. Antioxidant Effects of Oral Ang-(1-7) Restore Insulin Pathway and RAS Components Ameliorating Cardiometabolic Disturbances in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1204342
Modern Language Association (MLA)
Figueiredo, Vivian Paulino…[et al.]. Antioxidant Effects of Oral Ang-(1-7) Restore Insulin Pathway and RAS Components Ameliorating Cardiometabolic Disturbances in Rats. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1204342
American Medical Association (AMA)
Figueiredo, Vivian Paulino& Barbosa, Maria Andrea& de Castro, Uberdan Guilherme Mendes& Zacarias, Aline Cruz& Bezerra, Frank Silva& de Sá, Renata Guerra…[et al.]. Antioxidant Effects of Oral Ang-(1-7) Restore Insulin Pathway and RAS Components Ameliorating Cardiometabolic Disturbances in Rats. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1204342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204342