The Impact of Fermented Wheat Germ Extract on Porcine Epithelial Cell Line Exposed to Deoxynivalenol and T-2 Mycotoxins
Joint Authors
Pomothy, Judit Mercédesz
Barna, Réka Fanni
Jerzsele, Ákos
Pászti-Gere, Erzsébet
Prokoly, Dorottya
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The effect of fermented wheat germ extract (FWGE) (Immunovet®) was evaluated with cotreatments with deoxynivalenol (DON) and T-2 toxin (T-2).
These mycotoxins are produced by Fusarium mold species.
The effects of FWGE on IPEC-J2 with DON and T-2 have not been studied until now.
The IPEC-J2 porcine, nontumorigenic cell line was selected to investigate the outcome of the individually and simultaneously added compounds, as it has in vivo-like properties.
The cells were treated for 24 h with the selected solutions; then, the IPEC-J2 cells were allowed to regenerate in a culture medium for an additional 24 h.
In our results, DON and T-2 significantly increased the adverse impacts on cell viability and integrity of the cell monolayer.
To elucidate the extent of oxidative stress, extracellular H2O2 concentrations and intracellular reactive oxygen species (ROS) were measured.
FWGE appeared to be beneficial to IPEC-J2 cells given the separately and significantly decreased ROS levels.
1% and 2% FWGE could significantly reduce mycotoxin-induced oxidative stress.
In conclusion, the results demonstrate that FWGE exerted protective effects to counteract the oxidative stress-provoking properties of applied fusariotoxins in the nontumorigenic IPEC-J2 cell line.
American Psychological Association (APA)
Pomothy, Judit Mercédesz& Pászti-Gere, Erzsébet& Barna, Réka Fanni& Prokoly, Dorottya& Jerzsele, Ákos. 2020. The Impact of Fermented Wheat Germ Extract on Porcine Epithelial Cell Line Exposed to Deoxynivalenol and T-2 Mycotoxins. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1204370
Modern Language Association (MLA)
Pomothy, Judit Mercédesz…[et al.]. The Impact of Fermented Wheat Germ Extract on Porcine Epithelial Cell Line Exposed to Deoxynivalenol and T-2 Mycotoxins. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1204370
American Medical Association (AMA)
Pomothy, Judit Mercédesz& Pászti-Gere, Erzsébet& Barna, Réka Fanni& Prokoly, Dorottya& Jerzsele, Ákos. The Impact of Fermented Wheat Germ Extract on Porcine Epithelial Cell Line Exposed to Deoxynivalenol and T-2 Mycotoxins. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1204370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204370