Effects of Microvesicles on Cell Apoptosis under Hypoxia
Joint Authors
Guo, Ying
Tan, Jin
Miao, Yuyang
Zhang, Qiang
Sun, Zuoming
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hypoxia, as one of the severe cellular stresses, can cause cellular injury and even cell death.
Apoptosis is the main mechanism of regulating cell death and is closely related to the cell death caused by hypoxia.
However, hypoxia-induced apoptosis is not entirely the result of direct hypoxic stimulus of cells.
In recent years, it has been found that cells injured by hypoxia can shed a kind of membranous vesicles, which are called microvesicles (MVs).
MVs can carry bioactive molecules from injured mother cells and appear in blood, cerebrospinal fluid, and other body fluids.
MVs can induce normal cell apoptosis by transferring bioactive molecules into adjacent cells and amplifying the hypoxic injury in an organism.
This review summarizes the characteristic changes of MVs derived from hypoxic cells and the mechanism of normal cell apoptosis mediated by hypoxic cell-derived MVs.
Finally, we introduce the significance of this apoptosis-apoptosis cascade reaction in hypoxic diseases.
American Psychological Association (APA)
Guo, Ying& Tan, Jin& Miao, Yuyang& Sun, Zuoming& Zhang, Qiang. 2019. Effects of Microvesicles on Cell Apoptosis under Hypoxia. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204378
Modern Language Association (MLA)
Guo, Ying…[et al.]. Effects of Microvesicles on Cell Apoptosis under Hypoxia. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1204378
American Medical Association (AMA)
Guo, Ying& Tan, Jin& Miao, Yuyang& Sun, Zuoming& Zhang, Qiang. Effects of Microvesicles on Cell Apoptosis under Hypoxia. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204378