CD38cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms
Joint Authors
Dogan, Soner
Deshpande, Deepak A.
Guedes, Alonso G. P.
Graeff, Richard
Subramanian, Subbaya
Walseth, Timothy F.
Kannan, Mathur S.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness.
Inflammatory cytokines alter calcium (Ca2+) signaling and contractility of airway smooth muscle, which results in nonspecific airway hyperresponsiveness to agonists.
In this context, Ca2+ regulatory mechanisms in airway smooth muscle and changes in these regulatory mechanisms encompass a major component of airway hyperresponsiveness.
Although dynamic Ca2+ regulation is complex, phospholipase C/inositol tris-phosphate (PLC/IP3) and CD38-cyclic ADP-ribose (CD38/cADPR) are two major pathways mediating agonist-induced Ca2+ regulation in airway smooth muscle.
Altered CD38 expression or enhanced cyclic ADP-ribosyl cyclase activity associated with CD38 contributes to human pathologies such as asthma, neoplasia, and neuroimmune diseases.
This review is focused on investigations on the role of CD38-cyclic ADP-ribose signaling in airway smooth muscle in the context of transcriptional and posttranscriptional regulation of CD38 expression.
The specific roles of transcription factors NF-kB and AP-1 in the transcriptional regulation of CD38 expression and of miRNAs miR-140-3p and miR-708 in the posttranscriptional regulation and the underlying mechanisms of such regulation are discussed.
American Psychological Association (APA)
Deshpande, Deepak A.& Guedes, Alonso G. P.& Graeff, Richard& Dogan, Soner& Subramanian, Subbaya& Walseth, Timothy F.…[et al.]. 2018. CD38cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1204381
Modern Language Association (MLA)
Deshpande, Deepak A.…[et al.]. CD38cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms. Mediators of Inflammation No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1204381
American Medical Association (AMA)
Deshpande, Deepak A.& Guedes, Alonso G. P.& Graeff, Richard& Dogan, Soner& Subramanian, Subbaya& Walseth, Timothy F.…[et al.]. CD38cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1204381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204381