Lepidium meyenii Walp Exhibits Anti-Inflammatory Activity against ConA-Induced Acute Hepatitis
Joint Authors
Li, Xiao
Zheng, Wei
Zou, Junhui
Xu, Wang
Li, Tiyuan
Fu, Yanling
Wu, Shipin
Li, Chang
Du, Shouwen
Tian, Mingyao
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Strong inflammation is a prominent pathogenesis of acute hepatitis, which can induce hepatocyte death and lead to liver failure.
Lepidium meyenii Walp (Maca) is a traditional herbal medicine mostly used in improving sperm motility and serum hormone levels, etc.
However, there are no reports that showed Maca was designed for treating hepatitis so far.
Therefore, the protective effects and pharmacological mechanisms of Maca are unknown in hepatitis.
In this study, we found that the protective effects of Maca extract ameliorate ConA-induced acute hepatitis (CIH) and underlying mechanisms.
We determined that pretreatment with Maca extract significantly suppressed the production of aminotransferases and inflammatory cytokines, including IFN-γ, TNF-α, IL-1β, IL-2, IL-6, IL-12, and IL-17a, and moderated acute liver injury in CIH.
Maca recruited more myeloid-derived suppressor cells (MDSCs) to the liver and suppressed infiltration of natural killer T cells (NKT cells) and macrophages in the liver.
Furthermore, our data indicated the molecular mechanism of the inhibitory inflammatory effects of Maca, which should suppress the activation of NF-κB, IFN-γ/STAT1, and IL-6/STAT3 signalings.
Collectively, this present research explores Maca as an effective hepatoprotective medicine to inhibit inflammation and liver injury caused by acute hepatitis.
American Psychological Association (APA)
Zheng, Wei& Du, Shouwen& Tian, Mingyao& Xu, Wang& Zou, Junhui& Li, Tiyuan…[et al.]. 2018. Lepidium meyenii Walp Exhibits Anti-Inflammatory Activity against ConA-Induced Acute Hepatitis. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204385
Modern Language Association (MLA)
Zheng, Wei…[et al.]. Lepidium meyenii Walp Exhibits Anti-Inflammatory Activity against ConA-Induced Acute Hepatitis. Mediators of Inflammation No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1204385
American Medical Association (AMA)
Zheng, Wei& Du, Shouwen& Tian, Mingyao& Xu, Wang& Zou, Junhui& Li, Tiyuan…[et al.]. Lepidium meyenii Walp Exhibits Anti-Inflammatory Activity against ConA-Induced Acute Hepatitis. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204385