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MicroRNA-29b Enhances Osteoclast Survival by Targeting BCL-2-Modifying Factor after Lipopolysaccharide Stimulation
Joint Authors
Sul, Ok-Joo
Rajasekaran, Monisha
Park, Hyun-Jung
Suh, Jae-Hee
Choi, Hye-Sun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Recent findings suggest that microRNAs (miRs) play a critical role in osteoclastogenesis, which regulates bone loss.
We hypothesized that inflammation induces miR-29b, which increases the survival rate in osteoclasts (OCs), leading to bone loss.
The expression level of miR-29b increased in OC stimulated by lipopolysaccharide (LPS) in an in vitro system which correlated with its increase in tibiae from mice that received LPS injections compared with those that received vehicle treatment.
An miR-29b mimic increased OC survival rate without any change in OC differentiation, and furthermore, the inhibition of endogenous miR-29b induced by LPS decreased OC survival rate.
Increased OC survival rate after overexpression of miR-29b was associated with antiapoptotic activity, as shown by staining annexin V-positive cells.
We found that a target gene of miR-29b is BCL-2-modifying factor (Bmf), which acts as a proapoptotic factor, and that miR-29b binds to the 3′-UTR of Bmf.
Our data demonstrate that LPS-induced miR-29b increases the number of OC by enhancing OC survival through decreased BMF.
American Psychological Association (APA)
Sul, Ok-Joo& Rajasekaran, Monisha& Park, Hyun-Jung& Suh, Jae-Hee& Choi, Hye-Sun. 2019. MicroRNA-29b Enhances Osteoclast Survival by Targeting BCL-2-Modifying Factor after Lipopolysaccharide Stimulation. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204389
Modern Language Association (MLA)
Sul, Ok-Joo…[et al.]. MicroRNA-29b Enhances Osteoclast Survival by Targeting BCL-2-Modifying Factor after Lipopolysaccharide Stimulation. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1204389
American Medical Association (AMA)
Sul, Ok-Joo& Rajasekaran, Monisha& Park, Hyun-Jung& Suh, Jae-Hee& Choi, Hye-Sun. MicroRNA-29b Enhances Osteoclast Survival by Targeting BCL-2-Modifying Factor after Lipopolysaccharide Stimulation. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204389