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Sodium Tanshinone IIA Silate Exerts Microcirculation Protective Effects against Spinal Cord Injury In Vitro and In Vivo
Joint Authors
Hou, Yonghui
Luo, Dan
Hou, Yu
Li, Xing
Chen, Shudong
Zhan, Jiheng
Luan, Jiyao
Wang, Le
Lin, Dingkun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-08
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Spinal cord microcirculation involves functioning endothelial cells at the blood spinal cord barrier (BSCB) and maintains normal functioning of spinal cord neurons, axons, and glial cells.
Protection of both the function and integrity of endothelial cells as well as the prevention of BSCB disruption may be a strong strategy for the treatment of spinal cord injury (SCI) cases.
Sodium Tanshinone IIA silate (STS) is used for the treatment of coronary heart disease and improves microcirculation.
Whether STS exhibits protective effects for SCI microcirculation is not yet clear.
The purpose of this study is to investigate the protective effects of STS on oxygen-glucose deprivation- (OGD-) induced injury of spinal cord endothelial cells (SCMECs) in vitro and to explore effects on BSCB and neurovascular protection in vivo.
SCMECs were treated with various concentrations of STS (1 μM, 3 μM, and 10 μM) for 24 h with or without OGD-induction.
Cell viability, tube formation, migration, and expression of Notch signaling pathway components were evaluated.
Histopathological evaluation (H&E), Nissl staining, BSCB permeability, and the expression levels of von Willebrand Factor (vWF), CD31, NeuN, and Notch signaling pathway components were analyzed.
STS was found to improve SCMEC functions and reduce inflammatory mediators after OGD.
STS also relieved histopathological damage, increased zonula occludens-1 (ZO-1), inhibited BSCB permeability, rescued microvessels, protected motor neuromas, and improved functional recovery in a SCI model.
Moreover, we uncovered that the Notch signaling pathway plays an important role during these processes.
These results indicated that STS protects microcirculation in SCI, which may be used as a therapeutic strategy for SCI in the future.
American Psychological Association (APA)
Li, Xing& Luo, Dan& Hou, Yu& Hou, Yonghui& Chen, Shudong& Zhan, Jiheng…[et al.]. 2020. Sodium Tanshinone IIA Silate Exerts Microcirculation Protective Effects against Spinal Cord Injury In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1204400
Modern Language Association (MLA)
Li, Xing…[et al.]. Sodium Tanshinone IIA Silate Exerts Microcirculation Protective Effects against Spinal Cord Injury In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1204400
American Medical Association (AMA)
Li, Xing& Luo, Dan& Hou, Yu& Hou, Yonghui& Chen, Shudong& Zhan, Jiheng…[et al.]. Sodium Tanshinone IIA Silate Exerts Microcirculation Protective Effects against Spinal Cord Injury In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1204400
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204400