Higd1a Protects Cells from Lipotoxicity under High-Fat Exposure
Joint Authors
Li, Tong
Xian, Wen-jing
Gao, Yang
Jiang, Shuai
Yu, Qi-hong
Zheng, Qi-chang
Zhang, Yong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-08
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Hypoxia-inducible gene domain family member 1A (Higd1a) has recently been reported to protect cells from hypoxia by helping to maintain normal mitochondrial function.
The potential induction of Higd1a under high-fat exposure and whether it could protect cells from oxidative stress attracted our attention.
Initially, 0.4 mM oleic acid and 0.2 mM palmitate were added to the growth media of HepG2 and LO2 cells for 72 hours.
We discovered increased Higd1a expression, and knocking down Higd1a impaired mitochondrial transmembrane potential and induced cell apoptosis.
We then identified that elevated reactive oxygen species (ROS) is responsible for increased Higd1a expression.
Furthermore, we found that ROS promoted Higd1a expression by upregulating HIF-1a and PGC-1a expressions, and these two proteins could exert synergistic effects in inducing Higd1a expression.
Taken together, these data suggest that Higd1a plays positive roles in protecting cells from oxidative stress, and ROS could induce Higd1a expression by upregulating PGC-1a and HIF-1a expressions.
American Psychological Association (APA)
Li, Tong& Xian, Wen-jing& Gao, Yang& Jiang, Shuai& Yu, Qi-hong& Zheng, Qi-chang…[et al.]. 2019. Higd1a Protects Cells from Lipotoxicity under High-Fat Exposure. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1204433
Modern Language Association (MLA)
Li, Tong…[et al.]. Higd1a Protects Cells from Lipotoxicity under High-Fat Exposure. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1204433
American Medical Association (AMA)
Li, Tong& Xian, Wen-jing& Gao, Yang& Jiang, Shuai& Yu, Qi-hong& Zheng, Qi-chang…[et al.]. Higd1a Protects Cells from Lipotoxicity under High-Fat Exposure. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1204433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204433