Maternal Plasma Metabolomic Profiles in Spontaneous Preterm Birth: Preliminary Results
Joint Authors
Laudanski, Piotr
Lemancewicz, Adam
Charkiewicz, Karol
Miltyk, Wojciech
Lizewska, Barbara
Teul, Joanna
Kuc, Pawel
Goscik, Joanna
Kacerovsky, Marian
Menon, Ramkumar
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objective.
To profile maternal plasma metabolome in spontaneous preterm birth.
Method.
In this retrospective case-control study, we have examined plasma of patient with preterm birth (between 22 and 36 weeks of pregnancy (n=57)), with threatened preterm labor (between 23 and 36 weeks of pregnancy (n=49)), and with term delivery (n=25).
Plasma samples were analysed using liquid chromatography quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) in positive and negative polarity modes.
Results.
We found 168 differentially expressed metabolites that were significantly distinct between study groups.
We determined 51 metabolites using publicly available databases that could be subdivided into one of the five groups: amino acids, fatty acids, lipids, hormones, and bile acids.
PLS-DA models, verified by SVM classification accuracy, differentiated preterm birth and term delivery groups.
Conclusions.
Maternal plasma metabolites are different between term and preterm parturitions.
Part of them may be related with preterm labor, while others may be affected by gestational age or the beginning of labor.
Metabolite profile can classify preterm or term delivery groups raising the potential of metabolome as a biomarker to identify high-risk pregnancies.
Metabolomic studies are also a tool to detect individual compounds that may be further tested in targeted researches.
American Psychological Association (APA)
Lizewska, Barbara& Teul, Joanna& Kuc, Pawel& Lemancewicz, Adam& Charkiewicz, Karol& Goscik, Joanna…[et al.]. 2018. Maternal Plasma Metabolomic Profiles in Spontaneous Preterm Birth: Preliminary Results. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1204449
Modern Language Association (MLA)
Lizewska, Barbara…[et al.]. Maternal Plasma Metabolomic Profiles in Spontaneous Preterm Birth: Preliminary Results. Mediators of Inflammation No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1204449
American Medical Association (AMA)
Lizewska, Barbara& Teul, Joanna& Kuc, Pawel& Lemancewicz, Adam& Charkiewicz, Karol& Goscik, Joanna…[et al.]. Maternal Plasma Metabolomic Profiles in Spontaneous Preterm Birth: Preliminary Results. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1204449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204449