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Increased Expression of TLR10 in B Cell Subsets Correlates with Disease Activity in Rheumatoid Arthritis
Joint Authors
Ying, Haijian
Du, Juping
Zhang, Ying
Cao, Rong
Chen, Shuaishuai
Wang, Na
Shen, Bo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Toll-like receptor (TLR) 10, mainly expressed on B cells, has emerged as a modulatory receptor in inflammation.
Nonetheless, the clinical significance of TLR10 in rheumatoid arthritis (RA) remains unclear.
In this study, we explored the expression of TLR10 in B cells and B cell subsets in RA subjects and healthy controls (HCs) and determined its relevance to disease activity and inflammatory biomarkers.
TLR10 levels in B cells and B cell subsets (CD19+CD27+, CD19+CD27−, CD27+IgD−, CD27+IgD+, CD27−IgD+, D27−IgD−, CD19+CD5+, and CD19+CD5−) and inflammatory biomarker concentrations in peripheral blood (PB) obtained from RA subjects and HCs were detected by flow cytometry and enzyme-linked immunosorbent assay (ELISA), respectively.
The correlations of TLR10 expression with disease activity and inflammatory biomarkers were then analysed.
Similar levels of TLR10 in all CD19+ B cells were observed in the RA subjects and HCs.
Compared to that in the HCs, TLR10 was elevated significantly in the CD19+CD27−IgD− and CD19+CD5+ subsets in the RA subjects.
In addition, almost all subsets expressing TLR10 were increased with disease activity.
The present study reveals that enhanced TLR10 in B cell subsets is positively correlated with disease activity in RA subjects.
American Psychological Association (APA)
Zhang, Ying& Cao, Rong& Ying, Haijian& Du, Juping& Chen, Shuaishuai& Wang, Na…[et al.]. 2018. Increased Expression of TLR10 in B Cell Subsets Correlates with Disease Activity in Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1204458
Modern Language Association (MLA)
Zhang, Ying…[et al.]. Increased Expression of TLR10 in B Cell Subsets Correlates with Disease Activity in Rheumatoid Arthritis. Mediators of Inflammation No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1204458
American Medical Association (AMA)
Zhang, Ying& Cao, Rong& Ying, Haijian& Du, Juping& Chen, Shuaishuai& Wang, Na…[et al.]. Increased Expression of TLR10 in B Cell Subsets Correlates with Disease Activity in Rheumatoid Arthritis. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1204458
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204458