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Identification of Six Flavonoids as Novel Cellular Antioxidants and Their Structure-Activity Relationship
Joint Authors
Yang, Wenbo
Zhang, Chunling
Liu, Jiechao
Jiao, Zhonggao
Zhang, Qiang
Lv, Zhenzhen
Chen, Dalei
Liu, Hui
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study is aimed at determining the relationship of flavonoid structures to their chemical and intracellular antioxidant activities.
The antioxidant activities of 60 flavonoids were investigated by three different antioxidant assays, including 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, oxygen radical absorption capacity (ORAC), and cellular antioxidant activity (CAA) assays.
The result showed 6 flavonoids as good cellular antioxidants evaluated for the first time.
The cellular antioxidant activities of compounds 7-methoxy-quercetin, 3-O-methylquercetin, 8-hydroxy-kaempferol, quercetin-3-O-α-arabinofuranose, kaempferol-7-O-glucopyranoside, and luteolin6-C-glucoside were linked with the upregulation of antioxidant enzyme activities (superoxide dismutase, catalase, and glutathione peroxidase).
A structure-activity relationship suggested that 2,3-double bond, 4-keto groups, 3′,4′-catechol structure, and 3-hydroxyl in the flavonoid skeleton played important roles in the antioxidant behavior.
Furthermore, the cell proliferative assay revealed a low cytotoxicity for 3-O-methylquercetin.
The present results provide valuable information for the dietary application of flavonoids with different structures for high antioxidant.
American Psychological Association (APA)
Zhang, Qiang& Yang, Wenbo& Liu, Jiechao& Liu, Hui& Lv, Zhenzhen& Zhang, Chunling…[et al.]. 2020. Identification of Six Flavonoids as Novel Cellular Antioxidants and Their Structure-Activity Relationship. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204467
Modern Language Association (MLA)
Zhang, Qiang…[et al.]. Identification of Six Flavonoids as Novel Cellular Antioxidants and Their Structure-Activity Relationship. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1204467
American Medical Association (AMA)
Zhang, Qiang& Yang, Wenbo& Liu, Jiechao& Liu, Hui& Lv, Zhenzhen& Zhang, Chunling…[et al.]. Identification of Six Flavonoids as Novel Cellular Antioxidants and Their Structure-Activity Relationship. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204467
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204467