Probiotic Mixture Protects Dextran Sulfate Sodium-Induced Colitis by Altering Tight Junction Protein Expressions and Increasing Tregs
Joint Authors
Zhao, Xiaojing
Zhang, Hongjie
Zhang, Yingdi
Zhu, Yunjuan
Ma, Jingjing
Ma, Haiqin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Bifico is a probiotic mixture containing Bifidobacterium, Lactobacillus acidophilus, and Enterococcus.
Studies support that Bifico has a protective effect in experimental colitis (IL-10-deficient and TNBS) models and in patients with inflammatory bowel disease (IBD).
However, the mechanism underlying the protective effects of this mixture of probiotic bacteria remains incompletely clear.
Here, we investigated the effect of Bifico on intestinal inflammation.
In an in vivo experiment, dextran sulfate sodium was used to induce colitis.
Bifico treatment significantly attenuated the severity of colitis in this model.
Bifico increased the expression of tight junction proteins (TJs).
In addition, Bifico increased the number of Tregs, but reduced the number of total CD4+ T cells in the peripheral blood.
Furthermore, the expression of colonic CD4 protein was decreased while the level of forkhead box P3 (Foxp3) was upregulated.
These results suggested that Bifico exerts beneficial effects on experimental colitis by increasing the expressions of TJs, upregulating the number of Tregs, and reducing the total CD4+ T cell number in both colon and peripheral blood.
The intestinal damage in the pretreated + treated-Bifico-colitis group was more severe than that in only the pretreated-Bifico-colitis group.
This suggested that Bifico might aggravate intestinal damage when the mucosal barrier is impaired.
American Psychological Association (APA)
Zhang, Yingdi& Zhao, Xiaojing& Zhu, Yunjuan& Ma, Jingjing& Ma, Haiqin& Zhang, Hongjie. 2018. Probiotic Mixture Protects Dextran Sulfate Sodium-Induced Colitis by Altering Tight Junction Protein Expressions and Increasing Tregs. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204469
Modern Language Association (MLA)
Zhang, Yingdi…[et al.]. Probiotic Mixture Protects Dextran Sulfate Sodium-Induced Colitis by Altering Tight Junction Protein Expressions and Increasing Tregs. Mediators of Inflammation No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1204469
American Medical Association (AMA)
Zhang, Yingdi& Zhao, Xiaojing& Zhu, Yunjuan& Ma, Jingjing& Ma, Haiqin& Zhang, Hongjie. Probiotic Mixture Protects Dextran Sulfate Sodium-Induced Colitis by Altering Tight Junction Protein Expressions and Increasing Tregs. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204469
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204469