ZYZ-803 Mitigates Endoplasmic Reticulum Stress-Related Necroptosis after Acute Myocardial Infarction through Downregulating the RIP3-CaMKII Signaling Pathway
Joint Authors
Zhu, Yizhun
Xie, Ying
Wang, Zhijun
Chang, Lingling
Ma, Fenfen
Tran, Bahieu
Zhong, Rui
Xiong, Ying
Dai, Tao
Wu, Jian
Xin, Xiaoming
Mao, Yicheng
Guo, Wei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-02
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality worldwide, and both cardiac necroptosis and endoplasmic reticulum stress (ERS) have been involved in the pathophysiology of AMI.
ZYZ-803 is a hybrid molecule of a dual donor for gasotransmitters H2S and NO.
The aim of the present study is to investigate the antinecroptosis role and potential mechanisms of ZYZ-803 in the setting of ERS during AMI injury.
In vivo, ZYZ-803 preserves cardiac function and reduces infarct size significantly after 24-hour left coronary artery ligation through revising H2S and NO imbalance.
In addition, ZYZ-803 relieves ERS and necroptosis in an AMI heart.
In vitro, ZYZ-803 ameliorates ERS-related necroptosis induced by tunicamycin, and such effect has been depending on the receptor-interacting protein 3- (RIP3-) Ca2+-calmodulin-dependent protein kinase (CaMKII) signaling pathway.
These findings have identified a novel antinecroptosis potential of ZYZ-803, providing a valuable candidate for cardioprotection in acute myocardial ischemia.
American Psychological Association (APA)
Chang, Lingling& Wang, Zhijun& Ma, Fenfen& Tran, Bahieu& Zhong, Rui& Xiong, Ying…[et al.]. 2019. ZYZ-803 Mitigates Endoplasmic Reticulum Stress-Related Necroptosis after Acute Myocardial Infarction through Downregulating the RIP3-CaMKII Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1204479
Modern Language Association (MLA)
Chang, Lingling…[et al.]. ZYZ-803 Mitigates Endoplasmic Reticulum Stress-Related Necroptosis after Acute Myocardial Infarction through Downregulating the RIP3-CaMKII Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-18.
https://search.emarefa.net/detail/BIM-1204479
American Medical Association (AMA)
Chang, Lingling& Wang, Zhijun& Ma, Fenfen& Tran, Bahieu& Zhong, Rui& Xiong, Ying…[et al.]. ZYZ-803 Mitigates Endoplasmic Reticulum Stress-Related Necroptosis after Acute Myocardial Infarction through Downregulating the RIP3-CaMKII Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1204479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204479