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Neuroprotective Role of the Nrf2 Pathway in Subarachnoid Haemorrhage and Its Therapeutic Potential
Joint Authors
Bulters, Diederik
Galea, Ian
Zolnourian, Ardalan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
The mechanisms underlying poor outcome following subarachnoid haemorrhage (SAH) are complex and multifactorial.
They include early brain injury, spreading depolarisation, inflammation, oxidative stress, macroscopic cerebral vasospasm, and microcirculatory disturbances.
Nrf2 is a global promoter of the antioxidant and anti-inflammatory response and has potential protective effects against all of these mechanisms.
It has been shown to be upregulated after SAH, and Nrf2 knockout animals have poorer functional and behavioural outcomes after SAH.
There are many agents known to activate the Nrf2 pathway.
Of these, the actions of sulforaphane, curcumin, astaxanthin, lycopene, tert-butylhydroquinone, dimethyl fumarate, melatonin, and erythropoietin have been studied in SAH models.
This review details the different mechanisms of injury after SAH including the contribution of haemoglobin (Hb) and its breakdown products.
It then summarises the evidence that the Nrf2 pathway is active and protective after SAH and finally examines the evidence supporting Nrf2 upregulation as a therapy after SAH.
American Psychological Association (APA)
Zolnourian, Ardalan& Galea, Ian& Bulters, Diederik. 2019. Neuroprotective Role of the Nrf2 Pathway in Subarachnoid Haemorrhage and Its Therapeutic Potential. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-21.
https://search.emarefa.net/detail/BIM-1204498
Modern Language Association (MLA)
Zolnourian, Ardalan…[et al.]. Neuroprotective Role of the Nrf2 Pathway in Subarachnoid Haemorrhage and Its Therapeutic Potential. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-21.
https://search.emarefa.net/detail/BIM-1204498
American Medical Association (AMA)
Zolnourian, Ardalan& Galea, Ian& Bulters, Diederik. Neuroprotective Role of the Nrf2 Pathway in Subarachnoid Haemorrhage and Its Therapeutic Potential. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-21.
https://search.emarefa.net/detail/BIM-1204498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204498