Pistacia lentiscus Hydrosol: Untargeted Metabolomic Analysis and Anti-Inflammatory Activity Mediated by NF-κB and the Citrate Pathway
Joint Authors
D’Angelo, Salvatore
Santarsiero, Anna
Onzo, Alberto
Pascale, Raffaella
Acquavia, Maria Assunta
Coviello, Marianna
Convertini, Paolo
Todisco, Simona
Marsico, Michela
Pifano, Corrado
Iannece, Patrizia
Gaeta, Carmine
Padula, Maria Carmela
Bianco, Giuliana
Infantino, Vittoria
Martelli, Giuseppe
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-02
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Pistacia lentiscus shows a long range of biological activities, and it has been used in traditional medicine for treatment of various kinds of diseases.
Moreover, related essential oil keeps important health-promoting properties.
However, less is known about P.
lentiscus hydrosol, a main by-product of essential oil production, usually used for steam distillation itself or discarded.
In this work, by using ultra-high-resolution ESI(+)-FT-ICR mass spectrometry, a direct identification of four main classes of metabolites of P.
lentiscus hydrosol (i.e., terpenes, amino acids, peptides, and condensed heterocycles) was obtained.
Remarkably, P.
lentiscus hydrosol exhibited an anti-inflammatory activity by suppressing the secretion of IL-1β, IL-6, and TNF-α proinflammatory cytokines in lipopolysaccharide- (LPS-) activated primary human monocytes.
In LPS-triggered U937 cells, it inhibited NF-κB, a key transcription factor in inflammatory cascade, regulating the expression of both the mitochondrial citrate carrier and the ATP citrate lyase genes.
These two main components of the citrate pathway were downregulated by P.
lentiscus hydrosol.
Therefore, the levels of ROS, NO, and PGE2, the inflammatory mediators downstream the citrate pathway, were reduced.
Results shed light on metabolic profile and anti-inflammatory properties of P.
lentiscus hydrosol, suggesting its potential as a therapeutic agent.
American Psychological Association (APA)
Santarsiero, Anna& Onzo, Alberto& Pascale, Raffaella& Acquavia, Maria Assunta& Coviello, Marianna& Convertini, Paolo…[et al.]. 2020. Pistacia lentiscus Hydrosol: Untargeted Metabolomic Analysis and Anti-Inflammatory Activity Mediated by NF-κB and the Citrate Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204501
Modern Language Association (MLA)
Santarsiero, Anna…[et al.]. Pistacia lentiscus Hydrosol: Untargeted Metabolomic Analysis and Anti-Inflammatory Activity Mediated by NF-κB and the Citrate Pathway. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1204501
American Medical Association (AMA)
Santarsiero, Anna& Onzo, Alberto& Pascale, Raffaella& Acquavia, Maria Assunta& Coviello, Marianna& Convertini, Paolo…[et al.]. Pistacia lentiscus Hydrosol: Untargeted Metabolomic Analysis and Anti-Inflammatory Activity Mediated by NF-κB and the Citrate Pathway. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204501
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204501