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NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases
Joint Authors
Tong, Yeqing
Wang, Zhihong
Cai, Li
Lin, Liangqiang
Liu, Jiafa
Cheng, Jinquan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background/Aims.
NLRP3 inflammasome, an inflammasome which consists of nucleotide-binding oligomerization domain- (Nod-) like receptor3 (NLRP3) scaffold, apoptosis-associated speck-like protein (ASC) containing a CARD adaptor, and pro-caspase-1, is assembled after the cytoplasmic leucine-rich repeats (LRRs) of NLRP3 sense pathogens or danger signals.
In recent years, the role of inflammasome in cardiovascular diseases has attracted mounting attention, and the in-depth study of its mechanism is gradually clear.
Materials.
The NLRP3 inflammasome controls the activation of the proteolytic enzyme caspase-1.
Caspase-1 in turn regulates the maturation of the proinflammasome cytokines IL-1β and IL-18, which leads to an inflammatory response.
We made a mini-review on the association of regulatory mechanisms of NLRP3 inflammasome with the development of cardiovascular diseases systematically based on the recent research studies.
Discussion.
The inflammasome plays an indispensable role in the development of atherosclerosis, coronary heart diseases (CHD), and heart ischemia-reperfusion (I/R) injury, and NLRP3 inflammasome may become a new target for the prevention and treatment of cardiovascular diseases.
Effective regulation of NLRP3 may help prevent or even treat cardiovascular diseases.
Conclusion.
This mini-review focuses on the association of regulatory mechanisms of NLRP3 inflammasome with the development of cardiovascular diseases, which may supply some important clues for future therapies and novel drug targets for cardiovascular diseases.
American Psychological Association (APA)
Tong, Yeqing& Wang, Zhihong& Cai, Li& Lin, Liangqiang& Liu, Jiafa& Cheng, Jinquan. 2020. NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1204506
Modern Language Association (MLA)
Tong, Yeqing…[et al.]. NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1204506
American Medical Association (AMA)
Tong, Yeqing& Wang, Zhihong& Cai, Li& Lin, Liangqiang& Liu, Jiafa& Cheng, Jinquan. NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1204506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204506