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Maternal Separation Induces Long-Term Alterations in the Cardiac Oxytocin Receptor and Cystathionine γ-Lyase Expression in Mice
Joint Authors
Braun, Anna
Gündel, Harald
Radermacher, Peter
McCook, Oscar
Wigger, Daniela C.
Gröger, Nicole
Lesse, Alexandra
Krause, Sabrina
Merz, Tamara
Bock, Jörg
Waller, Christiane
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We recently showed that blunt chest trauma reduced the expression of the myocardial oxytocin receptor (Oxtr), which was further aggravated by genetic deletion of the H2S-producing enzyme cystathionine γ-lyase (CSE).
Exogenous H2S supplementation restored myocardial Oxtr expression under these conditions.
Early life stress (ELS) is a risk factor for cardiovascular disease by affecting vascular and heart structures.
Therefore, we tested the hypotheses that (i) ELS affects cardiac Oxtr and CSE expressions and (ii) Oxtr and CSE expression patterns depend on the duration of stress exposure.
Thus, two stress paradigms were compared: long- and short-term separation stress (LTSS and STSS, respectively).
Cardiac Oxtr expression was differentially affected by the two stress paradigms with a significant reduction after LTSS and a significant increase after STSS.
CSE expression, which was significantly reduced in Oxtr-/- knockout hearts, was downregulated and directly related to Oxtr expression in LTSS hearts (r=0.657, p=0.012).
In contrast, CSE expression was not related to Oxtr upregulation in STSS.
Plasma Oxt levels were not affected by either ELS paradigm.
The coincidence of LTSS-induced reduction of cardiac Oxtr and reduced CSE expression may suggest a novel pathophysiological link between early life adversities and increased risk for the development of cardiovascular disorders in adulthood.
American Psychological Association (APA)
Wigger, Daniela C.& Gröger, Nicole& Lesse, Alexandra& Krause, Sabrina& Merz, Tamara& Gündel, Harald…[et al.]. 2020. Maternal Separation Induces Long-Term Alterations in the Cardiac Oxytocin Receptor and Cystathionine γ-Lyase Expression in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1204514
Modern Language Association (MLA)
Wigger, Daniela C.…[et al.]. Maternal Separation Induces Long-Term Alterations in the Cardiac Oxytocin Receptor and Cystathionine γ-Lyase Expression in Mice. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1204514
American Medical Association (AMA)
Wigger, Daniela C.& Gröger, Nicole& Lesse, Alexandra& Krause, Sabrina& Merz, Tamara& Gündel, Harald…[et al.]. Maternal Separation Induces Long-Term Alterations in the Cardiac Oxytocin Receptor and Cystathionine γ-Lyase Expression in Mice. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1204514
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204514