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Oxidative Stress-Mediated Blood-Brain Barrier (BBB) Disruption in Neurological Diseases
Joint Authors
Gao, Yonghong
Sun, Yikun
Song, Ke
Li, Yuanyuan
Zhang, Hanlai
An, Na
Wei, Yufei
Wang, Liqin
Tian, Chao
Yuan, Mengchen
Yan-Wei, Xing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-03
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
The blood-brain barrier (BBB), as a crucial gate of brain-blood molecular exchange, is involved in the pathogenesis of multiple neurological diseases.
Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and the scavenger system.
Since oxidative stress plays a significant role in the production and maintenance of the BBB, the cerebrovascular system is especially vulnerable to it.
The pathways that initiate BBB dysfunction include, but are not limited to, mitochondrial dysfunction, excitotoxicity, iron metabolism, cytokines, pyroptosis, and necroptosis, all converging on the generation of ROS.
Interestingly, ROS also provide common triggers that directly regulate BBB damage, parameters including tight junction (TJ) modifications, transporters, matrix metalloproteinase (MMP) activation, inflammatory responses, and autophagy.
We will discuss the role of oxidative stress-mediated BBB disruption in neurological diseases, such as hemorrhagic stroke, ischemic stroke (IS), Alzheimer’s disease (AD), Parkinson’s disease (PD), traumatic brain injury (TBI), amyotrophic lateral sclerosis (ALS), and cerebral small vessel disease (CSVD).
This review will also discuss the latest clinical evidence of potential biomarkers and antioxidant drugs towards oxidative stress in neurological diseases.
A deeper understanding of how oxidative stress damages BBB may open up more therapeutic options for the treatment of neurological diseases.
American Psychological Association (APA)
Song, Ke& Li, Yuanyuan& Zhang, Hanlai& An, Na& Wei, Yufei& Wang, Liqin…[et al.]. 2020. Oxidative Stress-Mediated Blood-Brain Barrier (BBB) Disruption in Neurological Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-27.
https://search.emarefa.net/detail/BIM-1204523
Modern Language Association (MLA)
Song, Ke…[et al.]. Oxidative Stress-Mediated Blood-Brain Barrier (BBB) Disruption in Neurological Diseases. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-27.
https://search.emarefa.net/detail/BIM-1204523
American Medical Association (AMA)
Song, Ke& Li, Yuanyuan& Zhang, Hanlai& An, Na& Wei, Yufei& Wang, Liqin…[et al.]. Oxidative Stress-Mediated Blood-Brain Barrier (BBB) Disruption in Neurological Diseases. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-27.
https://search.emarefa.net/detail/BIM-1204523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204523