Redox Balance Correlates with Nutritional Status among Patients with End-Stage Renal Disease Treated with Maintenance Hemodialysis
Joint Authors
Ceranowicz, Piotr
Kuśnierz-Cabala, Beata
Kuźniewski, Marek
Gawlik, K.
Gala-Błądzińska, Agnieszka
Ząbek-Adamska, Anna
Maraj, Małgorzata
Pawlica-Gosiewska, Dorota
Dumnicka, Paulina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Over 50% of end-stage renal disease (ESRD) patients die of cardiovascular disease.
ESRD patients treated with maintenance hemodialysis are repeatedly exposed to oxidative stress.
The aim of the study was to find the relationship between lifestyle factors, nutritional status, calcium-phosphate metabolism, and selected redox parameters such as glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD), uric acid (UA), and total antioxidant capacity expressed as ferric reducing antioxidant power (FRAP).
The study included 97 ESRD hemodialysis patients and 42 controls with no renal disease.
Patients were asked to complete a questionnaire which gathered information on their physical activity, hours of sleep, smoking, and frequency of fruit and vegetable intake; the blood samples were then drawn before the midweek dialysis session.
The ESRD patients had lower levels of GR, GPx, and SOD activity, a lower level of FRAP, and a higher UA concentration than the control group.
The FRAP value decreased with age (ρ=−0.32, p=0.001); smokers had a significantly lower SOD activity in comparison to nonsmokers (p=0.03).
In the ESRD patients, FRAP and UA correlated with both albumin (ρ=0.26, p=0.011; ρ=0.41, p=0.006, respectively) and prealbumin (ρ=0.34, p≤0.001; ρ=0.28, p=0.006, respectively), whereas UA, GR, GPx, and SOD correlated with calcium, UA, GR, and GPx with phosphate level.
Based on the findings, there are weak associations between nutritional status and selected redox parameters in hemodialyzed patients.
Further studies are needed to establish if diet modifications and adequate nutritional status can positively impact the antioxidant capacity in this group of patients.
American Psychological Association (APA)
Maraj, Małgorzata& Kuśnierz-Cabala, Beata& Dumnicka, Paulina& Gawlik, K.& Pawlica-Gosiewska, Dorota& Gala-Błądzińska, Agnieszka…[et al.]. 2019. Redox Balance Correlates with Nutritional Status among Patients with End-Stage Renal Disease Treated with Maintenance Hemodialysis. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1204533
Modern Language Association (MLA)
Maraj, Małgorzata…[et al.]. Redox Balance Correlates with Nutritional Status among Patients with End-Stage Renal Disease Treated with Maintenance Hemodialysis. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1204533
American Medical Association (AMA)
Maraj, Małgorzata& Kuśnierz-Cabala, Beata& Dumnicka, Paulina& Gawlik, K.& Pawlica-Gosiewska, Dorota& Gala-Błądzińska, Agnieszka…[et al.]. Redox Balance Correlates with Nutritional Status among Patients with End-Stage Renal Disease Treated with Maintenance Hemodialysis. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1204533
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204533