Minireview on the Relations between Gut Microflora and Parkinson’s Disease: Further Biochemical (Oxidative Stress), Inflammatory, and Neurological Particularities
Joint Authors
Ciobica, Alin
Ilie, Ovidiu-Dumitru
McKenna, Jack
Doroftei, Bogdan
Mavroudis, Ioannis
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-05
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The aetiology of Parkinson’s disease (PD) is a highly debated topic.
Despite the progressive increase in the number of patients diagnosed with PD over the last couple of decades, the causes remain largely unknown.
This report is aimed at highlighting the main features of the microbial communities which have been termed “the second brain” that may be a major participant in the etiopathophysiology of PD.
It is possible that dysbiosis could be caused by an overactivity of proinflammatory cytokines which act on the gastrointestinal tract as well as infections.
The majority of patients who are diagnosed with PD display gastrointestinal symptoms as one of the earliest features.
In addition, an unbalanced cycle of oxidative stress caused by dysbacteriosis may have the effect of gradually promoting PD’s specific phenotype.
Thus, it seems that bacteria possess the ability to manipulate the brain by initiating specific responses, defining their capability to configure the human body, with oxidative stress playing a pivotal role in preventing infections but also in activating related signalling pathways.
American Psychological Association (APA)
Ilie, Ovidiu-Dumitru& Ciobica, Alin& McKenna, Jack& Doroftei, Bogdan& Mavroudis, Ioannis. 2020. Minireview on the Relations between Gut Microflora and Parkinson’s Disease: Further Biochemical (Oxidative Stress), Inflammatory, and Neurological Particularities. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1204534
Modern Language Association (MLA)
Ilie, Ovidiu-Dumitru…[et al.]. Minireview on the Relations between Gut Microflora and Parkinson’s Disease: Further Biochemical (Oxidative Stress), Inflammatory, and Neurological Particularities. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1204534
American Medical Association (AMA)
Ilie, Ovidiu-Dumitru& Ciobica, Alin& McKenna, Jack& Doroftei, Bogdan& Mavroudis, Ioannis. Minireview on the Relations between Gut Microflora and Parkinson’s Disease: Further Biochemical (Oxidative Stress), Inflammatory, and Neurological Particularities. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1204534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204534