Neuroglobin: A Novel Player in the Oxidative Stress Response of Cancer Cells
Joint Authors
Fiocchetti, Marco
Fernandez, Virginia Solar
Montalesi, Emiliano
Marino, Maria
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Reactive oxygen species (ROS) result from intracellular aerobic metabolism and/or extracellular stimuli.
Although endogenous antioxidant systems exquisitely balance ROS production, an excess of ROS production, commonly found in diverse human degenerative pathologies including cancer, gives rise to the oxidative stress.
Increased oxidative stress in cancer is related to the sustained proliferation and metabolism of cancer cells.
However, cancer cells show an intrinsic higher antioxidant capacity with respect to the normal counterpart as well as an ability to cope with oxidative stress-induced cell death by establishing mechanisms of adaptation, which define a selective advantage against the adverse oxidative stress environment.
The identification of survival factors and adaptive pathways, set up by cancer cells against oxidative stress, provides multiple targets for the therapeutic intervention against cancer.
Neuroglobin (NGB), a globin primarily described in neurons as an oxidative stress sensor and cytoprotective factor against redox imbalance, has been recently recognized as a novel tumor-associated protein.
In this review, the involvement of NGB in the cancer cell adaptation and resistance to oxidative stress will be discussed highlighting the globin role in the regulation of both the stress-induced apoptotic pathway and antioxidant systems activated by cancer cells.
American Psychological Association (APA)
Fiocchetti, Marco& Fernandez, Virginia Solar& Montalesi, Emiliano& Marino, Maria. 2019. Neuroglobin: A Novel Player in the Oxidative Stress Response of Cancer Cells. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1204537
Modern Language Association (MLA)
Fiocchetti, Marco…[et al.]. Neuroglobin: A Novel Player in the Oxidative Stress Response of Cancer Cells. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1204537
American Medical Association (AMA)
Fiocchetti, Marco& Fernandez, Virginia Solar& Montalesi, Emiliano& Marino, Maria. Neuroglobin: A Novel Player in the Oxidative Stress Response of Cancer Cells. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1204537
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204537