Analysis of SIRT1 Expression in Plasma and in an In Vitro Model of Preeclampsia
Joint Authors
Sandrim, Valeria Cristina
Cavalli, Ricardo de Carvalho
Viana-Mattioli, Sarah
Nunes, Priscila
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Preeclampsia (PE) is a pregnancy-specific disorder that affects 3–8% expecting mothers worldwide being one of the main causes of maternal and fetal morbidity and mortality.
The search for altered circulating molecules in PE is an important target to better understand the pathophysiology of this disease.
Therefore, we evaluated Sirtuin-1 (SIRT1) concentration in plasma from healthy pregnant (HP) women, gestational hypertensive women (GH), and preeclampsia women (PE) via enzyme-linked immunosorbent assay (ELISA).
We also measured intracellular SIRT1 in HUVECs incubated with plasma from PE patients compared to HP and GH via Western Blot Assay.
Statistical differences were considered when p<0.05.
SIRT1 was downregulated in PE compared to HP and GH, both in plasma and in in vitro assay.
Similarly, SIRT1 was also reduced in pregnant women who subsequently developed PE (case) compared to women who had healthy pregnancies (control).
This reduction may be indicative of possible underlying pathophysiology mechanisms in PE.
American Psychological Association (APA)
Viana-Mattioli, Sarah& Nunes, Priscila& Cavalli, Ricardo de Carvalho& Sandrim, Valeria Cristina. 2020. Analysis of SIRT1 Expression in Plasma and in an In Vitro Model of Preeclampsia. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1204543
Modern Language Association (MLA)
Viana-Mattioli, Sarah…[et al.]. Analysis of SIRT1 Expression in Plasma and in an In Vitro Model of Preeclampsia. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1204543
American Medical Association (AMA)
Viana-Mattioli, Sarah& Nunes, Priscila& Cavalli, Ricardo de Carvalho& Sandrim, Valeria Cristina. Analysis of SIRT1 Expression in Plasma and in an In Vitro Model of Preeclampsia. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1204543
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204543