Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery
Joint Authors
Tang, Xiaole
Zheng, Hua
Luo, Ailin
Sun, Rao
Zhou, Biyun
Yu, Honghui
Li, Shiyong
Zhao, Yilin
Yan, Jing
Zhang, Jie
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Postoperative cognitive dysfunction (POCD) is a sever postsurgical neurological complication in the elderly population.
As the global acceleration of population ageing, POCD is proved to be a great challenge to the present labor market and healthcare system.
In the present study, our findings showed that tau acetylation mediated by SIRT1 deficiency resulted in tau hyperphosphorylation in the hippocampus of the aged POCD model and consequently contributed to cognitive impairment.
Interestingly, pretreatment with resveratrol almost restored the expression of SIRT1, reduced the levels of acetylated tau and hyperphosphorylated tau in the hippocampus, and improved the cognitive performance in the behavioral tests.
What is more, we observed that microglia-derived neuroinflammation resulting from SIRT1 inhibition in microglia probably aggravated the tau acetylation in cultured neurons in vitro.
Our findings supported the notion that activation SIRT1 provided dually beneficial effect in the aged POCD model.
Taken together, our findings provided the initial evidence that tau acetylation was associated with cognitive impairment in the aged POCD model and paved a promising avenue to prevent POCD by inhibiting tau acetylation in a SIRT1-dependent manner.
American Psychological Association (APA)
Yan, Jing& Luo, Ailin& Sun, Rao& Tang, Xiaole& Zhao, Yilin& Zhang, Jie…[et al.]. 2020. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204575
Modern Language Association (MLA)
Yan, Jing…[et al.]. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1204575
American Medical Association (AMA)
Yan, Jing& Luo, Ailin& Sun, Rao& Tang, Xiaole& Zhao, Yilin& Zhang, Jie…[et al.]. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204575