Effects of Lycium barbarum Polysaccharides on Health and Aging of C. elegans Depend on daf-12daf-16
Joint Authors
Jia, Ya
Kirunda, John Billy
Yang, Lijian
Zhang, Zhaokang
Zhou, Yannan
Fan, Haitao
Zhao, Yunjie
Zhan, Xuan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-10
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
As the global population ages, searching for drugs and functional foods which can slow down the aging process has attracted a number of researchers.
In this paper, the Lycium barbarum polysaccharides (LBP) extracted from Lycium barbarum was characterized and the effects of LBP on the aging and health of C.
elegans were studied.
Results showed that LBP can prolong the lifespan, improve the abilities to withstand environmental stress, enhance reproductive potentials, and maintain muscle integrity of C.
elegans.
By using genetically mutated C.
elegans strains, RNAi gene silencing, and measuring the mRNA expression level, it was demonstrated that the lifespan of C.
elegans was extended by LBP mainly through sir-2.1, daf-12, and daf-16.
The present study might provide a basis for further study of LBP as a food or drug to interfere with aging and reduce the incidence of age-related diseases.
American Psychological Association (APA)
Zhang, Zhaokang& Zhou, Yannan& Fan, Haitao& Kirunda, John Billy& Zhao, Yunjie& Zhan, Xuan…[et al.]. 2019. Effects of Lycium barbarum Polysaccharides on Health and Aging of C. elegans Depend on daf-12daf-16. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1204581
Modern Language Association (MLA)
Zhang, Zhaokang…[et al.]. Effects of Lycium barbarum Polysaccharides on Health and Aging of C. elegans Depend on daf-12daf-16. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1204581
American Medical Association (AMA)
Zhang, Zhaokang& Zhou, Yannan& Fan, Haitao& Kirunda, John Billy& Zhao, Yunjie& Zhan, Xuan…[et al.]. Effects of Lycium barbarum Polysaccharides on Health and Aging of C. elegans Depend on daf-12daf-16. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1204581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204581