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Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials
Joint Authors
Russo, M. A.
Sansone, Luigi
Limongi, Dolores
Aventaggiato, Michele
Vernucci, Enza
Tomino, Carlo
Molinari, Francesca
Tafani, Marco
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-09
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Mitochondria are the cellular center of energy production and of several important metabolic processes.
Mitochondrion health is maintained with a substantial intervention of mitophagy, a process of macroautophagy that degrades selectively dysfunctional and irreversibly damaged organelles.
Because of its crucial duty, alteration in mitophagy can cause functional and structural adjustment in the mitochondria, changes in energy production, loss of cellular adaptation, and cell death.
In this review, we discuss the dual role that mitophagy plays in cancer and age-related pathologies, as a consequence of oxidative stress, evidencing the triggering stimuli and mechanisms and suggesting the molecular targets for its therapeutic control.
Finally, a section has been dedicated to the interplay between mitophagy and therapies using nanoparticles that are the new frontier for a direct and less invasive strategy.
American Psychological Association (APA)
Vernucci, Enza& Tomino, Carlo& Molinari, Francesca& Limongi, Dolores& Aventaggiato, Michele& Sansone, Luigi…[et al.]. 2019. Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1204586
Modern Language Association (MLA)
Vernucci, Enza…[et al.]. Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-19.
https://search.emarefa.net/detail/BIM-1204586
American Medical Association (AMA)
Vernucci, Enza& Tomino, Carlo& Molinari, Francesca& Limongi, Dolores& Aventaggiato, Michele& Sansone, Luigi…[et al.]. Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1204586
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204586