Role of Nrf2 and Its Activators in Cardiocerebral Vascular Disease
Joint Authors
Cheng, Liangkai
Zhang, Hong
Wu, Fang
Cheng, Yuanyuan
Wang, Caiyan
Liu, Zhong-Qiu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-06
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Cardiocerebral vascular disease (CCVD) is a common disease with high morbidity, disability, and mortality.
Oxidative stress (OS) is closely related to the progression of CCVD.
Abnormal redox regulation leads to OS and overproduction of reactive oxygen species (ROS), which can cause biomolecular and cellular damage.
The Nrf2/antioxidant response element (ARE) signaling pathway is one of the most important defense systems against exogenous and endogenous OS injury, and Nrf2 is regarded as a vital pharmacological target.
The complexity of the CCVD pathological process and the current difficulties in conducting clinical trials have hindered the development of therapeutic drugs.
Furthermore, little is known about the role of the Nrf2/ARE signaling pathway in CCVD.
Clarifying the role of the Nrf2/ARE signaling pathway in CCVD can provide new ideas for drug design.
This review details the recent advancements in the regulation of the Nrf2/ARE system and its role and activators in common CCVD development.
American Psychological Association (APA)
Cheng, Liangkai& Zhang, Hong& Wu, Fang& Liu, Zhong-Qiu& Cheng, Yuanyuan& Wang, Caiyan. 2020. Role of Nrf2 and Its Activators in Cardiocerebral Vascular Disease. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1204590
Modern Language Association (MLA)
Cheng, Liangkai…[et al.]. Role of Nrf2 and Its Activators in Cardiocerebral Vascular Disease. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1204590
American Medical Association (AMA)
Cheng, Liangkai& Zhang, Hong& Wu, Fang& Liu, Zhong-Qiu& Cheng, Yuanyuan& Wang, Caiyan. Role of Nrf2 and Its Activators in Cardiocerebral Vascular Disease. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1204590
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204590