Oxidative Stress-Induced circHBEGF Promotes Extracellular Matrix Production via Regulating miR-646EGFR in Human Trabecular Meshwork Cells
Joint Authors
Wang, Chengzhi
Shen, Wencui
Huang, Bingqing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-24
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Primary open-angle glaucoma (POAG), a leading cause of irreversible vision loss, presents with increased prevalence and a higher degree of clinical severity in the world.
Growing evidence has shown that ncRNAs are involved in the fibrotic process, which is thought to be the proegumenal cause of POAG.
Here, we screened out a differentially expressed circRNA (named circHBEGF) in human trabecular meshwork cells (HTMCs) under oxidative stress, which is spliced from pre-HBEGF.
circHBEGF promotes the expression of extracellular matrix (ECM) genes (fibronectin and collagen I).
Further studies revealed that circHBEGF could competitively bind to miR-646 as a miRNA sponge to regulate EGFR expression in HTMCs.
Importantly, HBEGF can also activate EGF signaling pathways, through which can transcriptionally activate ECM genes in HTMCs.
In summary, this study investigates the functions and molecular mechanisms of oxidative stress-induced circHBEGF in the regulation of ECM production in HTMCs through the miR646/EGFR pathway.
These findings further elucidate the pathogenic mechanism and may identify novel targets for the molecular therapy of POAG.
American Psychological Association (APA)
Shen, Wencui& Wang, Chengzhi& Huang, Bingqing. 2020. Oxidative Stress-Induced circHBEGF Promotes Extracellular Matrix Production via Regulating miR-646EGFR in Human Trabecular Meshwork Cells. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204596
Modern Language Association (MLA)
Shen, Wencui…[et al.]. Oxidative Stress-Induced circHBEGF Promotes Extracellular Matrix Production via Regulating miR-646EGFR in Human Trabecular Meshwork Cells. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1204596
American Medical Association (AMA)
Shen, Wencui& Wang, Chengzhi& Huang, Bingqing. Oxidative Stress-Induced circHBEGF Promotes Extracellular Matrix Production via Regulating miR-646EGFR in Human Trabecular Meshwork Cells. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204596