Mitochondria as Potential Targets and Initiators of the Blue Light Hazard to the Retina
Joint Authors
Tao, Jin-Xin
Zhou, Wen-Chuan
Zhu, Xin-Gen
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-21
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Commercially available white light-emitting diodes (LEDs) have an intense emission in the range of blue light, which has raised a range of public concerns about their potential risks as retinal hazards.
Distinct from other visible light components, blue light is characterized by short wavelength, high energy, and strong penetration that can reach the retina with relatively little loss in damage potential.
Mitochondria are abundant in retinal tissues, giving them relatively high access to blue light, and chromophores, which are enriched in the retina, have many mitochondria able to absorb blue light and induce photochemical effects.
Therefore, excessive exposure of the retina to blue light tends to cause ROS accumulation and oxidative stress, which affect the structure and function of the retinal mitochondria and trigger mitochondria-involved death signaling pathways.
In this review, we highlight the essential roles of mitochondria in blue light-induced photochemical damage and programmed cell death in the retina, indicate directions for future research and preventive targets in terms of the blue light hazard to the retina, and suggest applying LED devices in a rational way to prevent the blue light hazard.
American Psychological Association (APA)
Tao, Jin-Xin& Zhou, Wen-Chuan& Zhu, Xin-Gen. 2019. Mitochondria as Potential Targets and Initiators of the Blue Light Hazard to the Retina. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-20.
https://search.emarefa.net/detail/BIM-1204620
Modern Language Association (MLA)
Tao, Jin-Xin…[et al.]. Mitochondria as Potential Targets and Initiators of the Blue Light Hazard to the Retina. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-20.
https://search.emarefa.net/detail/BIM-1204620
American Medical Association (AMA)
Tao, Jin-Xin& Zhou, Wen-Chuan& Zhu, Xin-Gen. Mitochondria as Potential Targets and Initiators of the Blue Light Hazard to the Retina. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-20.
https://search.emarefa.net/detail/BIM-1204620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204620