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Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts
Joint Authors
Fischer-Fodor, Eva
Pârvu, Alina E.
Pârvu, Marcel
Cătoi, A. F.
Andreicuț, Andra Diana
Ţigu, Adrian Bogdan
Irimie, Alexandru
Cenariu, M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The prodrug potential of Mahonia aquifolium, a plant used for centuries in traditional medicine, recently gained visibility in the literature, and the activity of several active compounds isolated from its extracts was studied on biologic systems in vitro and in vivo.
Whereas the antioxidative and antitumor activities of M.
aquifolium-derived compounds were studied at some extent, there are very few data about their outcome on the immune system and tumor cells.
To elucidate the M.
aquifolium potential immunomodulatory and antiproliferative effects, the bark, leaf, flower, green fruit, and ripe fruit extracts from the plant were tested on peripheral blood mononuclear cells and tumor cells.
The extracts exert fine-tuned control on the immune response, by modulating the CD25 lymphocyte activation pathway, the interleukin-10 signaling, and the tumor necrosis-alpha secretion in four distinct human peripheral blood mononuclear cell (PBMC) subpopulations.
M.
aquifolium extracts exhibit a moderate cytotoxicity and changes in the signaling pathways linked to cell adhesion, proliferation, migration, and apoptosis of the tumor cells.
These results open perspectives to further investigation of the M.
aquifolium extract prodrug potential.
American Psychological Association (APA)
Andreicuț, Andra Diana& Fischer-Fodor, Eva& Pârvu, Alina E.& Ţigu, Adrian Bogdan& Cenariu, M.& Pârvu, Marcel…[et al.]. 2019. Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1204624
Modern Language Association (MLA)
Andreicuț, Andra Diana…[et al.]. Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1204624
American Medical Association (AMA)
Andreicuț, Andra Diana& Fischer-Fodor, Eva& Pârvu, Alina E.& Ţigu, Adrian Bogdan& Cenariu, M.& Pârvu, Marcel…[et al.]. Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1204624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204624