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Possible Susceptibility Genes for Intervention against Chemotherapy-Induced Cardiotoxicity
Joint Authors
Gao, Yonghong
Shang, Hongcai
Yang, Xinyu
Dai, Qianqian
Zhong, Changming
Luo, Changyong
An, Na
Li, Guoping
Yang, Tao
Guan, Manke
Yang, Fan
Das, Saumya
Yan-Wei, Xing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-30, 30 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-13
Country of Publication
Egypt
No. of Pages
30
Main Subjects
Abstract EN
Recent therapeutic advances have significantly improved the short- and long-term survival rates in patients with heart disease and cancer.
Survival in cancer patients may, however, be accompanied by disadvantages, namely, increased rates of cardiovascular events.
Chemotherapy-related cardiac dysfunction is an important side effect of anticancer therapy.
While advances in cancer treatment have increased patient survival, treatments are associated with cardiovascular complications, including heart failure (HF), arrhythmias, cardiac ischemia, valve disease, pericarditis, and fibrosis of the pericardium and myocardium.
The molecular mechanisms of cardiotoxicity caused by cancer treatment have not yet been elucidated, and they may be both varied and complex.
By identifying the functional genetic variations responsible for this toxicity, we may be able to improve our understanding of the potential mechanisms and pathways of treatment, paving the way for the development of new therapies to target these toxicities.
Data from studies on genetic defects and pharmacological interventions have suggested that many molecules, primarily those regulating oxidative stress, inflammation, autophagy, apoptosis, and metabolism, contribute to the pathogenesis of cardiotoxicity induced by cancer treatment.
Here, we review the progress of genetic research in illuminating the molecular mechanisms of cancer treatment-mediated cardiotoxicity and provide insights for the research and development of new therapies to treat or even prevent cardiotoxicity in patients undergoing cancer treatment.
The current evidence is not clear about the role of pharmacogenomic screening of susceptible genes.
Further studies need to done in chemotherapy-induced cardiotoxicity.
American Psychological Association (APA)
Yang, Xinyu& Li, Guoping& Yang, Tao& Guan, Manke& An, Na& Yang, Fan…[et al.]. 2020. Possible Susceptibility Genes for Intervention against Chemotherapy-Induced Cardiotoxicity. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-30.
https://search.emarefa.net/detail/BIM-1204638
Modern Language Association (MLA)
Yang, Xinyu…[et al.]. Possible Susceptibility Genes for Intervention against Chemotherapy-Induced Cardiotoxicity. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-30.
https://search.emarefa.net/detail/BIM-1204638
American Medical Association (AMA)
Yang, Xinyu& Li, Guoping& Yang, Tao& Guan, Manke& An, Na& Yang, Fan…[et al.]. Possible Susceptibility Genes for Intervention against Chemotherapy-Induced Cardiotoxicity. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-30.
https://search.emarefa.net/detail/BIM-1204638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204638