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Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis
Joint Authors
Mahran, Yasmen F.
Hassan, Hanan M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Cisplatin (cis-diaminedichloroplatinum, CDDP) is a broad-spectrum antineoplastic agent.
However, CDDP has been blamed for its nephrotoxicity, which is the main dose-limiting adverse effect.
Ganoderma lucidum (GL), a medicinal mushroom, has antioxidant and inflammatory activities.
Therefore, this study is aimed at finding out the potential nephroprotection of GL against CDDP-induced nephrotoxicity in rats and the possible molecular mechanisms including the EGFR downstream signaling, apoptosis, and autophagy.
Methods.
Rats were given GL (500 mg/kg) for 10 days and a single injection of CDDP (12 mg/kg, i.p).
Results.
Nephrotoxicity was evidenced by a significant increase in renal indices and oxidative stress markers.
Additionally, CDDP showed a plethora of inflammatory and apoptotic responses as evidenced by a profound increase of HMGB-1, NF-κB, and caspase-3 expressions, whereas administration of GL significantly improved all these indices as well as the histopathological insults.
Renal expression of EGFR showed a similar trend after GL administration.
Furthermore, activation of autophagy protein, LC3 II, was found to be involved in GL-mediated nephroprotection correlated with the downregulation of apoptotic signaling, caspase-3 and terminal deoxynucleotidyl transferase (TDT) renal expressions.
Conclusion.
These results suggest that GL might have improved CDDP-induced nephrotoxicity through antioxidant, anti-inflammatory, and autophagy-mediated apoptosis mechanisms and that inhibition of EGFR signaling might be involved in nephroprotection.
American Psychological Association (APA)
Mahran, Yasmen F.& Hassan, Hanan M.. 2020. Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204653
Modern Language Association (MLA)
Mahran, Yasmen F.& Hassan, Hanan M.. Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1204653
American Medical Association (AMA)
Mahran, Yasmen F.& Hassan, Hanan M.. Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204653
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204653