Diazoxide Protects against Myocardial IschemiaReperfusion Injury by Moderating ERS via Regulation of the miR-10aIRE1 Pathway
Joint Authors
Cao, Song
Zhang, Lin
Cai, Shuang
Nie, Jia
Zhou, Wenjing
Zhang, Yu
Li, Ke
Wang, Haiying
Yu, Shouyang
Yu, Tian
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-08
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Nowadays, reperfusion is still the most effective treatment for ischemic heart disease.
However, cardiac reperfusion therapy would lead to reperfusion injury, which may have resulted from endoplasmic reticulum stress (ERS) during reperfusion.
Diazoxide (DZ) is a highly selective mitochondrial adenosine triphosphate-sensitive potassium channel opener.
Its protective effect on I/R injury has been confirmed in many organs such as the heart and brain.
However, the mechanism of its protective effect has not been fully elucidated.
MicroRNAs (miRNAs) are widely involved in pathologies of heart disease.
In this study, we found that miR-10a expression was highly upregulated in the myocardial I/R groups, and DZ treatment significantly reduced the expression of miR-10a.
More importantly, we found that DZ treatment can moderate ERS via regulation of the miR-10a/IRE1 pathway in the I/R and H/R models, thereby protecting myocardial H/R injury.
American Psychological Association (APA)
Zhang, Lin& Cai, Shuang& Cao, Song& Nie, Jia& Zhou, Wenjing& Zhang, Yu…[et al.]. 2020. Diazoxide Protects against Myocardial IschemiaReperfusion Injury by Moderating ERS via Regulation of the miR-10aIRE1 Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1204666
Modern Language Association (MLA)
Zhang, Lin…[et al.]. Diazoxide Protects against Myocardial IschemiaReperfusion Injury by Moderating ERS via Regulation of the miR-10aIRE1 Pathway. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1204666
American Medical Association (AMA)
Zhang, Lin& Cai, Shuang& Cao, Song& Nie, Jia& Zhou, Wenjing& Zhang, Yu…[et al.]. Diazoxide Protects against Myocardial IschemiaReperfusion Injury by Moderating ERS via Regulation of the miR-10aIRE1 Pathway. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1204666
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204666