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The Role of Antioxidants in Ameliorating Cyclophosphamide-Induced Cardiotoxicity
Joint Authors
Wondafrash, Dawit Zewdu
Ayza, Muluken Altaye
Berhe, Abera Hadgu
Zewdie, Kaleab Alemayehu
Tesfaye, Bekalu Amare
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The chemotherapeutic and immunosuppressive agent cyclophosphamide has previously been shown to induce complications within the setting of bone marrow transplantation.
More recently, cardiotoxicity has been shown to be a dose-limiting factor during cyclophosphamide therapy, and cardiooncology is getting wider attention.
Though mechanism of cyclophosphamide-induced cardiotoxicity is not completely understood, it is thought to encompass oxidative and nitrative stress.
As such, this review focuses on antioxidants and their role in preventing or ameliorating cyclophosphamide-induced cardiotoxicity.
It will give special emphasis to the cardioprotective effects of natural, plant-derived antioxidants that have garnered significant interest in recent times.
American Psychological Association (APA)
Ayza, Muluken Altaye& Zewdie, Kaleab Alemayehu& Tesfaye, Bekalu Amare& Wondafrash, Dawit Zewdu& Berhe, Abera Hadgu. 2020. The Role of Antioxidants in Ameliorating Cyclophosphamide-Induced Cardiotoxicity. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204680
Modern Language Association (MLA)
Ayza, Muluken Altaye…[et al.]. The Role of Antioxidants in Ameliorating Cyclophosphamide-Induced Cardiotoxicity. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1204680
American Medical Association (AMA)
Ayza, Muluken Altaye& Zewdie, Kaleab Alemayehu& Tesfaye, Bekalu Amare& Wondafrash, Dawit Zewdu& Berhe, Abera Hadgu. The Role of Antioxidants in Ameliorating Cyclophosphamide-Induced Cardiotoxicity. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204680