Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial Infarction
Joint Authors
Okoshi, K.
Batista, Diego Fernando
Polegato, Bertha Furlan
da Silva, Renata Candido
Claro, Renan Turini
Azevedo, Paula Shmidt
Fernandes, Ana Angélica
de Paiva, Sergio Alberto Rupp
Minicucci, Marcos Ferreira
Zornorff, Leonardo Antônio Mamede
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The objective of this study was to analyze the impact of different modalities and intensities of exercise training on cardiac remodeling started early after experimental myocardial infarction (MI).
Male Wistar rats, weighing 200–250 g, were subjected to experimental MI.
After 5 days, the animals were allocated into three experimental groups and observed for three months: S (sedentary control animals), C (animals subjected to continuous low-intensity training), and HIT (animals subjected to high-intensity interval training).
Low-intensity exercise training was performed at a treadmill speed corresponding to 40% VO2 max, which was kept unchanged throughout the entire session (i.e., continuous low-intensity training).
High-intensity interval training was performed in such a way that rats run during 3 min at 60% VO2 max, followed by 4-minute intervals at 85% VO2 max (i.e., high-intensity interval training).
After the follow-up period, we studied hypertrophy and ventricular geometry, functional alterations in vivo and in vitro, oxidative stress, apoptosis, and cardiac energetic metabolism.
Our data showed that both high-intensity interval and continuous low-intensity modalities improved cardiac energetic metabolism variables in comparison with sedentary infarcted animals.
In addition, high-intensity interval training decreased cardiac oxidative stress, associated with improved diastolic function.
On the other hand, the continuous low-intensity group showed impairment of cardiac function.
Therefore, altogether, our data suggest that high-intensity interval training could be the best modality for early physical exercise after MI and should be better studied in this clinical scenario.
American Psychological Association (APA)
Batista, Diego Fernando& Polegato, Bertha Furlan& da Silva, Renata Candido& Claro, Renan Turini& Azevedo, Paula Shmidt& Fernandes, Ana Angélica…[et al.]. 2020. Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial Infarction. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1204708
Modern Language Association (MLA)
Batista, Diego Fernando…[et al.]. Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial Infarction. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1204708
American Medical Association (AMA)
Batista, Diego Fernando& Polegato, Bertha Furlan& da Silva, Renata Candido& Claro, Renan Turini& Azevedo, Paula Shmidt& Fernandes, Ana Angélica…[et al.]. Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial Infarction. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1204708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204708