Ethanol Extract of Leaves of Cassia siamea Lam Protects against Diabetes-Induced Insulin Resistance, Hepatic, and Endothelial Dysfunctions in obob Mice
Joint Authors
Le Lay, Soazig
Koffi, Camille
Kamagaté, Mamadou
Soleti, Raffaella
Nitiema, Mathieu
Mallegol, Patricia
Hilairet, Gregory
Chaigneau, Julien
Boursier, Jerome
Die-Kakou, Henri Maxime
Andriantsitohaina, Ramaroson
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Despite long traditional utilization and some reports on the antihyperglycemic and antihyperlipidemic action of Cassia siamea, the mechanisms involved have not been investigated yet.
Thus, the objective of the present study was to investigate whether and how oral administration of the ethanolic extract of Cassia siamea Lam leaves (LECS) improves glucose and insulin homoeostasis, liver damage, and endothelial dysfunction in an experimental model of type 2 diabetes, the leptin-deficient ob/ob mice.
Oxidative stress and protein expression of insulin-dependent and insulin -independent signaling pathways were studied.
Obese (ob/ob) vs.
control (ob/+) mice were treated daily with intragastric administration of either vehicle or LECS (200 mg/kg, per day) for 4 weeks.
Fasting blood glucose, body weight, food intake, glucose and insulin tolerance, oxidative stress, and liver damage as well as vascular complications with respect to endothelial dysfunction were examined.
Administration of LECS in obese mice significantly reduced blood glucose and insulin levels, improved glucose tolerance and insulin sensitivity, and restored the increase of circulating AST and ALT without modification of body weight and food intake.
These effects were associated with increased activity of both insulin and AMPK pathways in the liver and skeletal muscles.
Of particular interest, administration of LECS in obese mice completely prevented the endothelial dysfunction resulting from an increased NO⋅ and decreased reactive oxygen species (ROS) production in the aorta.
Altogether, oral administration of LECS remarkably attenuates features of type 2 diabetes on glucose, hepatic inflammation, insulin resistance, endothelial function, and vascular oxidative stress, being as most of these effects are related to insulin-dependent and insulin-independent mechanisms.
Therefore, this study points for the therapeutic potential of Cassia siamea in correcting both metabolic and vascular alterations linked to type 2 diabetes.
American Psychological Association (APA)
Koffi, Camille& Soleti, Raffaella& Nitiema, Mathieu& Mallegol, Patricia& Hilairet, Gregory& Chaigneau, Julien…[et al.]. 2019. Ethanol Extract of Leaves of Cassia siamea Lam Protects against Diabetes-Induced Insulin Resistance, Hepatic, and Endothelial Dysfunctions in obob Mice. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204710
Modern Language Association (MLA)
Koffi, Camille…[et al.]. Ethanol Extract of Leaves of Cassia siamea Lam Protects against Diabetes-Induced Insulin Resistance, Hepatic, and Endothelial Dysfunctions in obob Mice. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1204710
American Medical Association (AMA)
Koffi, Camille& Soleti, Raffaella& Nitiema, Mathieu& Mallegol, Patricia& Hilairet, Gregory& Chaigneau, Julien…[et al.]. Ethanol Extract of Leaves of Cassia siamea Lam Protects against Diabetes-Induced Insulin Resistance, Hepatic, and Endothelial Dysfunctions in obob Mice. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204710