Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4NF-κBNLRP3 Inflammasome Pathway
Joint Authors
Liu, Chang
Qu, Kai
Tong, Yingmu
Feng, Yang
Li, Zeyu
Jia, Yifan
Zhang, Jingyao
Cui, Ruixia
Chen, Dongdong
Wang, Cong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Cholestatic liver injury, due to obstruction of the biliary tract or genetic defects, is often accompanied by progressive inflammation and liver fibrosis.
Methane-rich saline (MRS) has anti-inflammatory properties.
However, whether MRS can provide protective effect in cholestatic liver injury is still unclear.
In this study, Sprague-Dawley rats received bile duct ligation (BDL) to generate a cholestatic model followed by MRS treatment (10 mL/kg, ip treatment) every 12 h after the operation to explore the potential protective mechanism of MRS in cholestatic liver injury.
We found that MRS effectively improved liver function, alleviated liver pathological damage, and localized infiltration of inflammatory cells.
MRS treatment decreased the expression of hepatic fibrosis-associated proteins to alleviate liver fibrosis.
Furthermore, MRS treatment suppressed the TLR4/NF-κB pathway and further reduced the levels of proinflammatory factors.
Downregulation of NF-κB subsequently reduced the NLRP3 expression to inhibit pyroptosis.
Our data indicated that methane treatment prevented cholestatic liver injury via anti-inflammatory properties that involved the TLR4/NF-κB/NLRP3 signaling pathway.
American Psychological Association (APA)
Li, Zeyu& Chen, Dongdong& Jia, Yifan& Feng, Yang& Wang, Cong& Tong, Yingmu…[et al.]. 2019. Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4NF-κBNLRP3 Inflammasome Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1204716
Modern Language Association (MLA)
Li, Zeyu…[et al.]. Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4NF-κBNLRP3 Inflammasome Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1204716
American Medical Association (AMA)
Li, Zeyu& Chen, Dongdong& Jia, Yifan& Feng, Yang& Wang, Cong& Tong, Yingmu…[et al.]. Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4NF-κBNLRP3 Inflammasome Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1204716
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204716