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Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer’s Disease
Joint Authors
Abdel-Daim, Mohamed M.
Ashraf, Ghulam Md.
Uddin, Md. Sahab
Bin-Jumah, May
Mamun, Abdullah Al
Bin Bashar, Md. Fahim
Zaman, Sonia
Begum, Yesmin
Bulbul, Israt Jahan
Islam, Md. Siddiqul
Sarwar, Md. Shahid
Mathew, Bijo
Amran, Md. Shah
Mousa, Shaker A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-15
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that causes chronic cognitive dysfunction.
Most of the AD cases are late onset, and the apolipoprotein E (APOE) isoform is a key genetic risk factor.
The APOE gene has 3 key alleles in humans including APOE2, APOE3, and APOE4.
Among them, APOE4 is the most potent genetic risk factor for late-onset AD (LOAD), while APOE2 has a defensive effect.
Research data suggest that APOE4 leads to the pathogenesis of AD through various processes such as accelerated beta-amyloid aggregations that raised neurofibrillary tangle formation, cerebrovascular diseases, aggravated neuroinflammation, and synaptic loss.
However, the precise mode of actions regarding in what way APOE4 leads to AD pathology remains unclear.
Since APOE contributes to several pathological pathways of AD, targeting APOE4 might serve as a promising strategy for the development of novel drugs to combat AD.
In this review, we focus on the recent studies about APOE4-targeted therapeutic strategies that have been advanced in animal models and are being prepared for use in humans for the management of AD.
American Psychological Association (APA)
Mamun, Abdullah Al& Uddin, Md. Sahab& Bin Bashar, Md. Fahim& Zaman, Sonia& Begum, Yesmin& Bulbul, Israt Jahan…[et al.]. 2020. Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1204721
Modern Language Association (MLA)
Mamun, Abdullah Al…[et al.]. Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1204721
American Medical Association (AMA)
Mamun, Abdullah Al& Uddin, Md. Sahab& Bin Bashar, Md. Fahim& Zaman, Sonia& Begum, Yesmin& Bulbul, Israt Jahan…[et al.]. Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1204721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204721