Sex Differences in Age-Associated Type 2 Diabetes in Rats—Role of Estrogens and Oxidative Stress
Joint Authors
Abdelaziz, Kheira M.
Lopez-Grueso, R.
Mas-Bargues, C.
Díaz, Ana
Viña, Jose
Gambini, Juan
Monleón, Daniel
Borrás, Consuelo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Females live longer than males, and the estrogens are one of the reasons for this difference.
We reported some years ago that estrogens are able to protect rats against oxidative stress, by inducing antioxidant genes.
Type 2 diabetes is an age-associated disease in which oxidative stress is involved, and moreover, some studies show that the prevalence is higher in men than in women, and therefore there are sex-associated differences.
Thus, the aim of this study was to evaluate the role of estrogens in protecting against oxidative stress in type 2 diabetic males and females.
For this purpose, we used Goto-Kakizaki rats, which develop type 2 diabetes with age.
We found that female diabetic rats showed lower glycaemia levels with age than did diabetic males and that estrogens enhanced insulin sensitivity in diabetic females.
Moreover, glucose uptake, measured by positron emission tomography, was higher in the female brain, cerebellum, and heart than in those from male diabetic rats.
There were also sex-associated differences in the plasma metabolic profile as determined by metabolomics.
The metabolic profile was similar between estrogen-replaced and control diabetic rats and different from ovariectomized diabetic rats.
Oxidative stress is involved in these differences.
We showed that hepatic mitochondria from females produced less hydrogen peroxide levels and exhibited lower xanthine oxidase activity.
We also found that hepatic mitochondrial glutathione oxidation and lipid oxidation levels were lower in diabetic females when compared with diabetic males.
Ovariectomy induced oxidative stress, and estrogen replacement therapy prevented it.
These findings provide evidence for estrogen beneficial effects in type 2 diabetes and should be considered when prescribing estrogen replacement therapy to menopausal women.
American Psychological Association (APA)
Díaz, Ana& Lopez-Grueso, R.& Gambini, Juan& Monleón, Daniel& Mas-Bargues, C.& Abdelaziz, Kheira M.…[et al.]. 2019. Sex Differences in Age-Associated Type 2 Diabetes in Rats—Role of Estrogens and Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1204771
Modern Language Association (MLA)
Díaz, Ana…[et al.]. Sex Differences in Age-Associated Type 2 Diabetes in Rats—Role of Estrogens and Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1204771
American Medical Association (AMA)
Díaz, Ana& Lopez-Grueso, R.& Gambini, Juan& Monleón, Daniel& Mas-Bargues, C.& Abdelaziz, Kheira M.…[et al.]. Sex Differences in Age-Associated Type 2 Diabetes in Rats—Role of Estrogens and Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1204771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204771