Acrocomia aculeata (Jacq.) Lodd. ex Mart. Leaves Increase SIRT1 Levels and Improve Stress Resistance
Joint Authors
Campos, Jaqueline Ferreira
de Picoli Souza, Kely
Seiça, Raquel
Antunes, Kátia Avila
Alfredo, Tamaeh Monteiro
Cabral, Célia
Magalhães, M.
Iacia, Bianca Pancoti
dos Santos, Jéssica Maurino
da Silva Melo da Cunha, Janielle
Oliveira, Sara
Oliveira, Alex Santos
Cardoso, Cláudia Andrea Lima
de Oliveira, Caio Fernando Ramalho
dos Santos, Edson Lucas
Matafome, Paulo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-10
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Oxidative stress is a metabolic disorder linked with several chronic diseases, and this condition can be improved by natural antioxidants.
The fruit pulp of the palm Acrocomia aculeata (Jacq.) Lodd.
ex Mart.
is widely used in the treatment of various illnesses, but as far as we know, there are no reports regarding the properties of its leaves.
Thus, we aimed to evaluate the antioxidant activity of A.
aculeata leaf extracts obtained with water (EA-Aa), ethanol (EE-Aa), and methanol (EM-Aa) solvents.
The extracts were chemically characterized, and their antioxidant activity was assessed through the scavenging of the free radicals DPPH and ABTS.
EE-Aa and EM-Aa showed the highest amounts of phenolic compounds and free radical scavenging activity.
However, EA-Aa was more efficient to protect human erythrocytes against AAPH-induced hemolysis and lipid peroxidation.
Thus, we further show the antioxidant effect of EA-Aa in preventing AAPH-induced protein oxidation, H2O2-induced DNA fragmentation, and ROS generation in Cos-7 cells.
Increased levels of Sirt1, catalase, and activation of ERK and Nrf2 were observed in Cos-7 treated with EA-Aa.
We also verify increased survival in nematodes C.
elegans, when induced to the oxidative condition by Juglone.
Therefore, our results showed a typical chemical composition of plants for all extracts, but the diversity of compounds presented in EA-Aa is involved in the lower toxicity and antioxidant properties provided to the macromolecules tested, proteins, DNA, and lipids.
This protective effect also proven in Cos-7 and in C.
elegans was probably due to the activation of the Sirt1/Nrf2 pathway.
Altogether, the low toxicity and the antioxidant properties of EA-Aa showed in all the experimental models support its further use in the treatment of oxidative stress-related diseases.
American Psychological Association (APA)
Alfredo, Tamaeh Monteiro& Matafome, Paulo& Iacia, Bianca Pancoti& Antunes, Kátia Avila& dos Santos, Jéssica Maurino& da Silva Melo da Cunha, Janielle…[et al.]. 2020. Acrocomia aculeata (Jacq.) Lodd. ex Mart. Leaves Increase SIRT1 Levels and Improve Stress Resistance. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1204774
Modern Language Association (MLA)
Alfredo, Tamaeh Monteiro…[et al.]. Acrocomia aculeata (Jacq.) Lodd. ex Mart. Leaves Increase SIRT1 Levels and Improve Stress Resistance. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1204774
American Medical Association (AMA)
Alfredo, Tamaeh Monteiro& Matafome, Paulo& Iacia, Bianca Pancoti& Antunes, Kátia Avila& dos Santos, Jéssica Maurino& da Silva Melo da Cunha, Janielle…[et al.]. Acrocomia aculeata (Jacq.) Lodd. ex Mart. Leaves Increase SIRT1 Levels and Improve Stress Resistance. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1204774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204774