Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis
Joint Authors
Khatana, Chainika
Saini, Neeraj K.
Sharma, Anil
Saini, Reena V.
Saini, Adesh K.
Saini, Vipin
Chakrabarti, Sasanka
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-15
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Dyslipidaemia has a prominent role in the onset of notorious atherosclerosis, a disease of medium to large arteries.
Atherosclerosis is the prime root of cardiovascular events contributing to the most considerable number of morbidity and mortality worldwide.
Factors like cellular senescence, genetics, clonal haematopoiesis, sedentary lifestyle-induced obesity, or diabetes mellitus upsurge the tendency of atherosclerosis and are foremost pioneers to definitive transience.
Accumulation of oxidized low-density lipoproteins (Ox-LDLs) in the tunica intima triggers the onset of this disease.
In the later period of progression, the build-up plaques rupture ensuing thrombosis (completely blocking the blood flow), causing myocardial infarction, stroke, and heart attack, all of which are common atherosclerotic cardiovascular events today.
The underlying mechanism is very well elucidated in literature but the therapeutic measures remains to be unleashed.
Researchers tussle to demonstrate a clear understanding of treating mechanisms.
A century of research suggests that lowering LDL, statin-mediated treatment, HDL, and lipid-profile management should be of prime interest to retard atherosclerosis-induced deaths.
We shall brief the Ox-LDL-induced atherogenic mechanism and the treating measures in line to impede the development and progression of atherosclerosis.
American Psychological Association (APA)
Khatana, Chainika& Saini, Neeraj K.& Chakrabarti, Sasanka& Saini, Vipin& Sharma, Anil& Saini, Reena V.…[et al.]. 2020. Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204781
Modern Language Association (MLA)
Khatana, Chainika…[et al.]. Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1204781
American Medical Association (AMA)
Khatana, Chainika& Saini, Neeraj K.& Chakrabarti, Sasanka& Saini, Vipin& Sharma, Anil& Saini, Reena V.…[et al.]. Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204781