MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2
Joint Authors
Chen, Xia
Wang, Ai-li
Liu, Yuan-yuan
Zhao, Chen-xi
Zhou, Xue
Liu, Hai-long
Lin, Mo-bin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Colorectal cancer (CRC) is a leading cause of cancer-related death around the world whose recurrence and metastasis rate is high.
Due to the underlying unclear pathogenesis, it is hard so far to predict the tumorigenesis and prevent its recurrence.
YAP/TAZ has been reported to be activated and functioned as a potential oncogene in multiple cancer types and proved to be essential for the carcinogenesis of most solid tumors.
In the present study, we found that YAP/TAZ was markedly upregulated in CRC tissues comparing with the adjacent noncancerous tissues due to the downregulation of LATS2, the main upstream regulator.
We further identified miR-429 as a direct regulator of LATS2-YAP/TAZ activation, suggesting that the miR-429-LATS2-YAP/TAZ might be novel effective diagnostic axis and therapeutic targets for CRC.
American Psychological Association (APA)
Chen, Xia& Wang, Ai-li& Liu, Yuan-yuan& Zhao, Chen-xi& Zhou, Xue& Liu, Hai-long…[et al.]. 2020. MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204810
Modern Language Association (MLA)
Chen, Xia…[et al.]. MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1204810
American Medical Association (AMA)
Chen, Xia& Wang, Ai-li& Liu, Yuan-yuan& Zhao, Chen-xi& Zhou, Xue& Liu, Hai-long…[et al.]. MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204810
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204810