Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice
Joint Authors
Li, Bowen
Li, Luocheng
Hu, Xiaoping
Li, Baijun
Luo, Jinlong
Shen, Bin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The use of doxorubicin (DOX) can result in depression of cardiac function and refractory cardiomyopathy.
Currently, there are no effective approaches to prevent DOX-related cardiac complications.
Asiatic acid (AA) has been reported to provide cardioprotection against several cardiovascular diseases.
However, whether AA could attenuate DOX-related cardiac injury remains unclear.
DOX (15 mg/kg) was injected intraperitoneally into the mice to mimic acute cardiac injury, and the mice were given AA (10 mg/kg or 30 mg/kg) for 2 weeks for protection.
The data in our study found that AA-treated mice exhibited attenuated cardiac injury and improved cardiac function in response to DOX injection.
AA also suppressed myocardial oxidative damage and apoptosis without affecting cardiac inflammation in DOX-treated mice.
AA also provided protection in DOX-challenged cardiomyocytes, improved cell viability, and suppressed intracellular reactive oxygen species (ROS) in vitro.
Detection of signaling pathways showed that AA activated protein kinase B (AKT) signaling pathway in vivo and in vitro.
Furthermore, we found that AA lost its protective effects in the heart with AKT inactivation.
In conclusion, our results found that AA could attenuate DOX-induced myocardial oxidative stress and apoptosis via activation of the AKT signaling pathway.
American Psychological Association (APA)
Hu, Xiaoping& Li, Baijun& Li, Luocheng& Li, Bowen& Luo, Jinlong& Shen, Bin. 2020. Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204821
Modern Language Association (MLA)
Hu, Xiaoping…[et al.]. Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1204821
American Medical Association (AMA)
Hu, Xiaoping& Li, Baijun& Li, Luocheng& Li, Bowen& Luo, Jinlong& Shen, Bin. Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204821