Exploration of Cadmium Dioxide Nanoparticles on Bioaccumulation, Oxidative Stress, and Carcinogenic Potential in Oreochromis mossambicus L.
Joint Authors
Alarifi, Saud
Al-Abdan, Monera A.
Bin-Jumah, May N.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The field of nanotechnology is rapidly expanding with the advancement of novel nanopesticide and nanofertilizers that have the potential for revolutionizing applications in the agricultural industry.
Here, we have done chronic toxicity of cadmium dioxide nanoparticles (CdONPs) on fish Oreochromis mossambicus (O.
mossambicus) using oxidative stress and genotoxic biomarkers.
In this current study, the value of LC50-96 hr of CdONPs has observed 40 μg/ml for O.
mossambicus.
The three sublethal concentrations, e.g., 4, 10, and 20 μg/ml were selected based on the LC50 value.
The fishes were treated to the above concentration of CdONPs for 21 days and were harvested at 1, 7, 14, and 21 days for evaluation of clastogenicity, mutagenicity, and genotoxicity of NPs.
Generally, significant effects (p<0.01) were observed as a dose and duration of exposure.
It was observed that lipid peroxidation (LPO) was increased and glutathione was decreased in both tissues.
Micronuclei (MNi) were produced significantly in peripheral blood on 21 days at maximum concentration.
A similar trend was seen in the damage of DNA with the same manner in terms of the percentage of tail DNA in the lymphocyte, gills, and kidney cells.
This study explored the application oxidative stress, comet assay, and micronucleus assay for in situ aquatic laboratory studies using fish O.
mossambicus for screening the ecomutagenic and genotoxic potential of environmental pollutants.
American Psychological Association (APA)
Al-Abdan, Monera A.& Bin-Jumah, May N.& Alarifi, Saud. 2020. Exploration of Cadmium Dioxide Nanoparticles on Bioaccumulation, Oxidative Stress, and Carcinogenic Potential in Oreochromis mossambicus L.. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204848
Modern Language Association (MLA)
Al-Abdan, Monera A.…[et al.]. Exploration of Cadmium Dioxide Nanoparticles on Bioaccumulation, Oxidative Stress, and Carcinogenic Potential in Oreochromis mossambicus L.. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1204848
American Medical Association (AMA)
Al-Abdan, Monera A.& Bin-Jumah, May N.& Alarifi, Saud. Exploration of Cadmium Dioxide Nanoparticles on Bioaccumulation, Oxidative Stress, and Carcinogenic Potential in Oreochromis mossambicus L.. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204848
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204848